Sleep desaturation and its relationship to lung function, exercise and quality of life in LAM


Autoria(s): Medeiros, Pedro, Jr.; Lorenzi-Filho, Geraldo; Pimenta, Suzana P.; Kairalla, Ronaldo A.; Carvalho, Carlos R. R.
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

30/10/2013

30/10/2013

02/08/2013

Resumo

Background: Lymphangioleiomyomatosis (LAM) is characterised by progressive airway obstruction and hypoxaemia in young women. Although sleep may trigger hypoxaemia in patients with airway obstruction, it has not been previously investigated in patients with LAM. Methods: Consecutive women with lung biopsy proven LAM and absence of hypoxaemia while awake were evaluated with pulmonary function test, echocardiography, 6-min walk test, overnight full polysomnography, and Short Form 36 health-related quality-of-life questionnaire. Results: Twenty-five patients with (mean +/- SD) age 45 +/- 10 years, SpO(2) awake 95% +/- 2, forced expiratory volume in the first second (median-interquartile) FEV1 (% predicted) 77 (47-90) and carbonic monoxide diffusion capacity, DLCO (%) 55 (34-74) were evaluated. Six-minute walk test distance and minimum SpO(2) (median-interquartile) were, respectively, 447 m (411 -503) and 90% (82-94). Median interquartile apnoea-hypopnoea index was in the normal range 2 (1-5). Fourteen patients (56%) had nocturnal hypoxaemia (10% total sleep time with SpO(2) <90%), and the median sleep time spent with SpO(2) <90% was 136 (13-201) min. Sleep time spent with SpO(2) <90% correlated with the residual volume/total lung capacity ratio (r(s) = 0.5, p: 0.02), DLCO (r(s) = -0.7, p: 0.001), FEV1 (r(s) = -0.6, p: 0.002). Multivariate linear regression model showed that RV/TLC ratio was the most important functional variable related to sleep hypoxaemia. Conclusion: Significant hypoxaemia during sleep is common in LAM patients with normal SpO(2) while awake, especially among those with some degree of hyperinflation in lung function tests. (C) 2011 Published by Elsevier Ltd.

Hospital das Clinicas, University of Sao Paulo Medical School

Hospital das Clinicas, University of Sao Paulo Medical School [LIM-09]

Identificador

RESPIRATORY MEDICINE, LONDON, v. 106, n. 3, supl. 1, Part 3, pp. 420-428, MAR, 2012

0954-6111

http://www.producao.usp.br/handle/BDPI/36934

10.1016/j.rmed.2011.12.008

http://dx.doi.org/10.1016/j.rmed.2011.12.008

Idioma(s)

eng

Publicador

W B SAUNDERS CO LTD

LONDON

Relação

RESPIRATORY MEDICINE

Direitos

closedAccess

Copyright W B SAUNDERS CO LTD

Palavras-Chave #LYMPHANGIOLEIO MYOMATOSIS (LAM) #POLYSOMNOGRAPHY #SLEEP HYPOXAEMIA #SIX-MINUTE WALK TEST #LUNG FUNCTION TEST #OBSTRUCTIVE PULMONARY-DISEASE #6-MINUTE WALK TEST #OXYGEN DESATURATION #APNEA SYNDROME #FUNCTION TESTS #LYMPHANGIOLEIOMYOMATOSIS #HYPERTENSION #GUIDELINES #HYPOXEMIA #CARDIAC & CARDIOVASCULAR SYSTEMS #RESPIRATORY SYSTEM
Tipo

article

original article

publishedVersion