The functional role of ascending nociceptive control in defensive behavior
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
01/11/2013
01/11/2013
02/08/2013
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| Resumo |
Ascending nociceptive control is a novel spino-striato-rostral ventral medulla pain modulation pathway that mediates heterosegmental pain-induced analgesia, i.e., noxious stimulus-induced antinociception. In this study, we used the dorsal immobility response in rats as a model of the defensive responses. We demonstrated that the activation of ascending nociceptive control by peripheral noxious stimulation and spinal AMPA and mGluR1 receptor blockade significantly potentiated the duration of the dorsal immobility response in rats via an opioid-dependent mechanism in the nucleus accumbens. These results demonstrated the functional role of ascending nociceptive control in the modulation of defensive responses and spinal glutamatergic receptors in the dorsal immobility response. The immobility response is an antipredator behavior that reflects the underlying state of fear, and ascending nociceptive control may modulate fear. (c) 2012 Elsevier B.V. All rights reserved. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) |
| Identificador |
BRAIN RESEARCH, AMSTERDAM, v. 1464, n. 10, supl. 1, Part 6, pp. 24-29, 47270, 2012 0006-8993 http://www.producao.usp.br/handle/BDPI/37601 10.1016/j.brainres.2012.05.010 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCIENCE BV AMSTERDAM |
| Relação |
BRAIN RESEARCH |
| Direitos |
closedAccess Copyright ELSEVIER SCIENCE BV |
| Palavras-Chave | #NUCLEUS ACCUMBENS #NOXIOUS STIMULATION #ANALGESIA #ASCENDING NOCICEPTIVE CONTROL #DORSAL IMMOBILITY RESPONSE #DEFENSIVE RESPONSE #SPINAL GLUTAMATERGIC RECEPTOR #NUCLEUS-ACCUMBENS CIRCUITRY #DORSAL IMMOBILITY RESPONSE #TONIC IMMOBILITY #INDUCED ANTINOCICEPTION #SOMATOSTATIN ANALOGS #NOXIOUS-STIMULATION #PERIAQUEDUCTAL GRAY #OPIOID RECEPTORS #RAT #ANTAGONISTS #NEUROSCIENCES |
| Tipo |
article original article publishedVersion |
