Topoisomerase expression in oral squamous cell carcinoma: relationship with cancer stem cells profiles and lymph node metastasis
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
31/10/2013
31/10/2013
02/08/2013
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Resumo |
BACKGROUND: The relationship between predictive proteins and tumors presenting cancer stem cells (CSCs) profiles in oral tumors is still poorly understood. This study aims to identify the relationship between topoisomerases I, II alpha, and III alpha and putative CSCs immunophenotype in oral squamous cell carcinoma (OSCC) and determine its influence on prognosis. METHODS: The following data were retrieved from 127 patients: age, gender, primary anatomic site, smoking and alcohol intake, recurrence, metastases, histologic classification, treatment, and survival. An immunohistochemical study for topoisomerases I, II alpha, and III alpha was performed in a tissue microarray containing 127 paraffin blocks of OSCCs. RESULTS: In univariate analysis, topoisomerases expression showed significant differences according to CSCs profiles and p53 immunoexpression, but not with survival. Topoisomerases II alpha and III alpha also showed significant relationship with lymph node metastasis. The multivariate test confirmed these associations. CONCLUSIONS: The results that all topoisomerases correlates with OSCC CSCs may indicate a role for topoisomerases in head and neck carcinogenesis. Notwithstanding, it is plausible that other members of topoisomerases family could represent novel therapeutical targets in oral squamous cell carcinoma. J Oral Pathol Med (2012) 41: 762-768 Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2008/06461-1, 2010/08400-0] Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [472891/2010-3] Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) |
Identificador |
JOURNAL OF ORAL PATHOLOGY & MEDICINE, HOBOKEN, v. 41, n. 10, supl. 1, Part 6, pp. 762-768, NOV, 2012 0904-2512 http://www.producao.usp.br/handle/BDPI/37010 10.1111/j.1600-0714.2012.01174.x |
Idioma(s) |
eng |
Publicador |
WILEY-BLACKWELL HOBOKEN |
Relação |
JOURNAL OF ORAL PATHOLOGY & MEDICINE |
Direitos |
restrictedAccess Copyright WILEY-BLACKWELL |
Palavras-Chave | #LYMPH NODE METASTASIS #ORAL SQUAMOUS CELL CARCINOMA #PROGNOSIS #STEM CELLS #TOPOISOMERASE I #TOPOISOMERASE III ALPHA #TOPOISOMERASE II ALPHA #DNA TOPOISOMERASES #PHASE-II #HEAD #NECK #ALPHA #DOCETAXEL #CISPLATIN #RECURRENT #TRIAL #P53 #DENTISTRY, ORAL SURGERY & MEDICINE #PATHOLOGY |
Tipo |
article original article publishedVersion |