Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium

To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 casecontrol studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.590.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.420.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.540.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.160.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.

NCI, NIH

NIH, NCI [R03CA113157]

NIDCR [R03 DE016611]

NIDCR

Swiss League against Cancer

Swiss League against Cancer [KFS1069-09-2000]

Fribourg League gainst Cancer [FOR381.88]

Fribourg League gainst Cancer

Swiss Cancer Research

Swiss Cancer Research [AKT 617]

GustaveRoussy Institute

Gustave-Roussy Institute [88D28]

National Institutes of Health (NIH) US

National Institutes of Health (NIH) US [P01CA068384, K07CA104231, R01CA048896, R01DE012609, R01CA61188, R01DE13158, P50CA90388, R01DA11386, R03CA77954, T32CA09142, U01CA96134, R21ES011667, R01CA078609, R01CA100679]

National Institute of Environmental Health Sciences [P30ES010126]

National Institute of Environmental Health Sciences

UCLA Jonsson Comprehensive Cancer Center, IARC

UCLA Jonsson Comprehensive Cancer Center, IARC

National Institutes of Health (NCI) US

National Institutes of Health (NCI) US

NIDCR

NIDCR

Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina

Fondo para la Investigacion Cientifica y Tecnologica (FONCYT) Argentina

IMIM (Barcelona)

IMIM (Barcelona)

Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) [01/01768-2]

Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP)

European Commission

European Commission [IC18-CT97-0222]

Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government

Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government [FIS 97/0024, FIS 97/0662, BAE 01/5013]

International Union Against Cancer (UICC)

International Union Against Cancer (UICC)

YamagiwaYoshida Memorial International Cancer Study Grant

Yamagiwa-Yoshida Memorial International Cancer Study Grant

National Cancer Institute, National Institutes of Health, USA

National Cancer Institute, National Institutes of Health, USA

NIH

NIH [R01CA51845]

IARC

IARC