The use of Mitomycin-C to reduce synechia in middle meatus in sinus surgery: preliminary results


Autoria(s): Yamaoka, Wellington Yugo; Gregorio, Luis Carlos
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

01/11/2013

01/11/2013

02/08/2013

Resumo

Synechia is the most frequent complication after sinus surgery and has been reported in up to 36% of cases. Several types of materials have been used to reduce the incidence of synechia, including Mitomycin C (MMC). Objective: This prospective study aimed to assess the effectiveness of topical MMC in the prevention of synechia after sinus surgery in humans. Methods: At the end of surgery, MMC solution (1.0 mg/ml) was topically applied randomly to one of the middle meatuses (MMC group) of 14 patients while saline solution was applied to the contralateral meatus (control group). The author remained blind to the medicated side. Synechiae were classified as partial or total. Results: Three patients had middle meatus synechia in the MMC group (21.43%) versus nine (64.29%) in the control group (p = 0.054). In the MMC group, all three middle meatus synechia were partial, while in the control group there were four partial (28.57%) and five total (35.71%) cases of synechia (p = 0.025). Conclusions: Mitomycin C was not effective in preventing middle meatus synechia, but reduced the probability of total synechia formation.

Identificador

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, SAO PAULO, v. 78, n. 5, supl., Part 3, pp. 44-50, SEP-OCT, 2012

1808-8694

http://www.producao.usp.br/handle/BDPI/37254

10.5935/1808-8694.20120007

http://dx.doi.org/10.5935/1808-8694.20120007

Idioma(s)

eng

Publicador

ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL

SAO PAULO

Relação

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY

Direitos

openAccess

Copyright ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL

Palavras-Chave #MITOMYCIN #NATURAL ORIFICE ENDOSCOPIC SURGERY #POSTOPERATIVE COMPLICATIONS #ADHESION FORMATION #COMPLICATIONS #PREVENTION #STENOSIS #DACRYOCYSTORHINOSTOMY #PTERYGIUM #DROPS #OTORHINOLARYNGOLOGY
Tipo

article

original article

publishedVersion