Chemical mechanism of controlled nitric oxide release from trans-[RuCl([15]aneN(4))NO](PF6)(2) as a vasorelaxant agent
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
31/10/2013
31/10/2013
02/08/2013
|
| Resumo |
The nitrosyl ruthenium complex, trans-[RuCl([15]aneN(4))NO](PF6)(2), ([15]aneN(4) = 1,4,8,12-tetraazacyclopentadecane), exhibits vasorelaxation characteristics attributed to its nitric oxide release properties. The observed in vitro and in vivo vasodilation is dependent on noradrenaline concentration. We report here the chemical mechanism of the reaction between noradrenaline and trans-[RuCl([15]aneN(4))NO](PF6)(2) in aqueous phosphate buffer solution at pH 7.40. NO measurement by NO-sensor electrode, cyclic voltammetry, (PNMR)-P-31 and HPLC analysis were used to investigate the reduction process as the fundamental step for NO release characteristic of trans-[RuCl([15]aneN(4))NO](PF6)(2). A supramolecular species containing HPO4 (2-) as a bridging group between noradrenaline and trans-[RuCl([15]aneN(4))NO](PF6)(2) is suggested as an intermediate prior to the reduction of the nitrosyl ruthenium complex. CNPq CNPq CAPES CAPES FAPESP FAPESP |
| Identificador |
TRANSITION METAL CHEMISTRY, DORDRECHT, v. 37, n. 5, supl. 1, Part 6, pp. 475-479, AUG, 2012 0340-4285 http://www.producao.usp.br/handle/BDPI/37098 10.1007/s11243-012-9612-5 |
| Idioma(s) |
eng |
| Publicador |
SPRINGER DORDRECHT |
| Relação |
TRANSITION METAL CHEMISTRY |
| Direitos |
closedAccess Copyright SPRINGER |
| Palavras-Chave | #NITROSYL RUTHENIUM COMPLEX #RAT AORTA RELAXATION #LIGHT IRRADIATION #CATECHOLAMINES #NITROPRUSSIDE #OXIDATION #PHOSPHATE #DONORS #NO #CHEMISTRY, INORGANIC & NUCLEAR |
| Tipo |
article original article publishedVersion |
