Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
|---|---|
| Data(s) |
30/10/2013
30/10/2013
2012
|
| Resumo |
The retrovirus human T lymphotropic virus type 1 (HTLV-1) promotes spastic paraparesis, adult T cell leukaemia and other diseases. Recently, some human microRNAs (miRNAs) have been described as important factors in host-virus interactions. This study compared miRNA expression in control individuals, asymptomatic HTLV-1 carriers and HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis patients. The proviral load and Tax protein expression were measured in order to characterize the patients. hsa-miR-125b expression was significantly higher in patients than in controls (p = 0.0285) or in the HAM group (p = 0.0312). Therefore, our findings suggest that miR-125b expression can be used to elucidate the mechanisms of viral replication and pathogenic processes. FAPESP [06/59388-4] FAPESP CNPq CNPq FUNDHERP FUNDHERP |
| Identificador |
MEMORIAS DO INSTITUTO OSWALDO CRUZ, RIO DE JANEIRO, RJ, v. 107, n. 6, supl., Part 3, pp. 824-827, SEP, 2012 0074-0276 |
| Idioma(s) |
eng |
| Publicador |
FUNDACO OSWALDO CRUZ RIO DE JANEIRO, RJ |
| Relação |
MEMORIAS DO INSTITUTO OSWALDO CRUZ |
| Direitos |
openAccess Copyright FUNDACO OSWALDO CRUZ |
| Palavras-Chave | #HAM/TSP #HSA-MIR-125B #UPREGULATION #T-CELLS #MICRORNA MIR-125B #NAIVE #PCR #PARASITOLOGY #TROPICAL MEDICINE |
| Tipo |
article original article publishedVersion |
