CARNITINE SUPPLEMENTATION EFFECTS ON NONENZYMATIC ANTIOXIDANTS IN YOUNG RATS SUBMITTED TO EXHAUSTIVE EXERCISE STRESS


Autoria(s): Bucioli, Servio A.; De Abreu, Luiz C.; Valenti, Vitor E.; Vannucchi, Helio
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

30/10/2013

30/10/2013

02/08/2013

Resumo

Bucioli, SA, de Abreu, LC, Valenti, VE, and Vannucchi, H. Carnitine supplementation effects on nonenzymatic antioxidants in young rats submitted to exhaustive exercise stress. J Strength Cond Res 26(6): 1695-1700, 2012-Previous studies have demonstrated that exercise stress increases oxidative stress in rats. However, antioxidant supplement therapy effects on reactive oxygen substances are conflicting. We evaluated the effects of carnitine on renal nonenzymatic antioxidants in young rats submitted to exhaustive exercise stress. Wistar rats were divided into 3 groups: (a) control group (not submitted to exercise stress), (b) exercise stress group, and (c) exercise stress and carnitine group. The rats from group 3 were treated with gavage administration of 1 ml of carnitine (5 mg.kg(-1)) for 7 consecutive days. The animals from groups 2 and 3 were submitted to a bout of swimming exhaustive exercise stress. Kidney samples were analyzed for reactive substances to thiobarbituric acid by malondialdehyde (MDA), reduced glutathione (GSH), and vitamin-E levels. Carnitine treatment attenuated MDA increase caused by exercise stress (1:0.16 +/- 0.02 vs. 2:0.34 +/- 0.07 vs. 3:0.1 +/- 0.01 mmmol per milligram of protein; p < 0.0001). It also increased the renal levels of GSH (1:23 +/- 4 vs. 2:23 +/- 2 vs. 3:58 +/- 9 mu mol per gram of protein; p, 0.0001); however, it did not change renal vitamin E (1:24 +/- 5 vs. 2:27 +/- 1 vs. 3:28 +/- 5 mu M per gram of tissue; p < 0.001). In conclusion, carnitine improved oxidative stress and partially improved the nonenzymatic antioxidant activity in young rats submitted to exhaustive exercise stress.

Departamento de Clinica Medica da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo (USP)

Departamento de Clinica Medica da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo (USP)

Identificador

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, PHILADELPHIA, v. 26, n. 6, supl. 4, Part 1-2, pp. 1695-1700, JUN, 2012

1064-8011

http://www.producao.usp.br/handle/BDPI/36749

10.1519/JSC.0b013e318234ebcb

http://dx.doi.org/10.1519/JSC.0b013e318234ebcb

Idioma(s)

eng

Publicador

LIPPINCOTT WILLIAMS & WILKINS

PHILADELPHIA

Relação

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

Direitos

restrictedAccess

Copyright LIPPINCOTT WILLIAMS & WILKINS

Palavras-Chave #FREE RADICALS #CARNITINE #STRESS #EXERCISE #CARDIOMYOCYTES NUCLEAR SIZE #OXIDATIVE STRESS #COLD STRESS #ALPHA-TOCOPHEROL #HEALTHY-SUBJECTS #SKELETAL-MUSCLE #ENZYME-SYSTEM #VENTRICLE #INJURY #RESTRICTION #SPORT SCIENCES
Tipo

article

original article

publishedVersion