DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR DEYERMINATION OF ACYCLOVIR IN POLYMERIC NANOPARTICLES
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
29/10/2013
29/10/2013
2012
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Resumo |
A derivative spectrophotometric method was validated for quzintification of acyclovir in poly (n-butylcyanoacrylate) (PBCA) nanoparticles. Specificity, linearity. precision, accuracy, recovery. detection (LOD) and quantification (LOQ) Inuits were established for method validation. First-derivative it 295.2 nm eliminated interferences from nanoparticle ingredients and presented linearity for acyclovir concentrations ranging front 1.25 to 40.0 mu g/mL. (r = 0.9999). Precision and accuracy data demonstrated good reproducibility. Recovery ranged from 99.3 to 101.2. LOD) was 0.08 mu g/mL and LOQ. 0.25 mu g/mL. Thus. the proposed method proved to be easy. low cost. and accurate, and therefore, an useful alternative to quantify acyclovir in nanoparticles. CNPq CNPq CAPES CAPES |
Identificador |
QUIMICA NOVA, SAO PAULO, v. 35, n. 1, pp. 203-206, SEP-OCT, 2012 0100-4042 http://www.producao.usp.br/handle/BDPI/36345 10.1590/S0100-40422012000100035 |
Idioma(s) |
eng |
Publicador |
SOC BRASILEIRA QUIMICA SAO PAULO |
Relação |
QUIMICA NOVA |
Direitos |
openAccess Copyright SOC BRASILEIRA QUIMICA |
Palavras-Chave | #ACYCLOVIR #POLYMERIC NAMMARTICLES #DERIVATIVE SPECTROPHOTOMETRY #DRUG-DELIVERY #TRIMETHYL CHITOSAN #METHYLATION #CHEMISTRY, MULTIDISCIPLINARY |
Tipo |
article original article publishedVersion |