The density of metastatic lymph node as prognostic factor in squamous cell carcinoma of the tongue and floor of the mouth


Autoria(s): Amar, Ali; Rapoport, Abrao; Curioni, Otavio Alberto; Dedivitis, Rogerio Aparecido; Cernea, Claudio Roberto; Brandao, Lenine Garcia
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

24/10/2013

24/10/2013

2012

Resumo

The presence of metastatic lymph nodes is a relevant prognostic factor in oral cancer. Objective: This paper aims to assess metastatic lymph node density (pN+) in patients with tongue and floor-of-mouth squamous cell carcinoma (SCC) and the association of this parameter with disease-free survival (DFS). Materials and Methods: A group of 182 patients seen between 1985 and 2007 was included, 169 of which were males. Five were on stage I, 35 on stage II, 56 on stage III, and 85 on stage IV. Median values were considered in lymph node density assessment, and the Kaplan-Meier curve was used to evaluate DFS; survival differences within the group were elicited through the log-rank test. Results: An average 3.2 metastatic lymph nodes were excised from the patients in the group. Density ranged from 0.009 to 0.4, with a mean value of 0.09. Five-year DFS rates were of 44% and 28% for the groups with lymph node densities below and above the median respectively (p = 0.006). Two-year local/regional control was achieved for 71% and 49% for the patients below and above the median density respectively (p = 0.01). In terms of pN staging, local/regional control was achieved in 70% and 54% of pN1 and pN2 patients respectively, albeit without statistical significance (0.20%). Conclusion: Lymph node density may be used as a prognostic indicator for tongue and floor-ofmouth SCC.

Identificador

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, SAO PAULO, v. 78, n. 3, supl., Part 3, pp. 86-90, MAY-JUN, 2012

1808-8694

http://www.producao.usp.br/handle/BDPI/35926

10.1590/S1808-86942012000300015

http://dx.doi.org/10.1590/S1808-86942012000300015

Idioma(s)

eng

Publicador

ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL

SAO PAULO

Relação

BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY

Direitos

openAccess

Copyright ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL

Palavras-Chave #LYMPH NODES #LYMPHATIC METASTASIS #MOUTH NEOPLASMS #PROGNOSIS #TONGUE NEOPLASMS #ORAL-CAVITY #CANCER #HEAD #SURVIVAL #OTORHINOLARYNGOLOGY
Tipo

article

original article

publishedVersion