DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
12/10/2013
12/10/2013
2012
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Resumo |
DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD FOR QUANTITATION OF THE DRUG BEVACIZUMAB BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. In this study, an analytical method was developed and validated for quantitation of the drug bevacizumab (Avastin (R)) by high performance liquid chromatography (HPLC). The HPLC column was a BioSuite 250 (R) HR SEC, 300 x 7.8 mm x 5 mu m (Waters, USA). The mobile phase consisted of phosphate buffered saline (PBS). The results revealed that the method was specific, precise. accurate, robust and linear (r(2) = 0.998) from 5 to 75 mu g mL(-1). Therefore, this method can be used in drug release studies or in quality control ampoules of the drug. |
Identificador |
QUIMICA NOVA, SAO PAULO, v. 35, n. 3, supl. 18, Part 2, pp. 608-611, MAY, 2012 0100-4042 http://www.producao.usp.br/handle/BDPI/34260 10.1590/S0100-40422012000300029 |
Idioma(s) |
por |
Publicador |
SOC BRASILEIRA QUIMICA SAO PAULO |
Relação |
QUIMICA NOVA |
Direitos |
openAccess Copyright SOC BRASILEIRA QUIMICA |
Palavras-Chave | #BEVACIZUMAB #HIGH PERFORMANCE LIQUID CHROMATOGRAPHY #VALIDATION #COHERENCE TOMOGRAPHY FINDINGS #INTRAVITREAL INJECTION #PHARMACOKINETICS #AVASTIN(R) #RABBITS #CHEMISTRY, MULTIDISCIPLINARY |
Tipo |
article original article publishedVersion |