DNA repair mechanisms protect our genome from carcinogenesis
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
22/10/2013
22/10/2013
2012
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Resumo |
Human cells are constantly exposed to DNA damage. Without repair, damage can result in genetic instability and eventually cancer. The strong association between the lack of DNA damage repair, mutations and cancer is dramatically demonstrated by a number of cancer-prone human syndromes, such as xeroderma pigmentosum (XP), ataxia-telangiectasia (AT) and Fanconi anemia (FA). This review focuses on the historical discoveries related with these three diseases and describes their impact on the understanding of DNA repair mechanisms and the causes of human cancer. As deficiencies in DNA repair are also often related with progeria symptoms, unrepaired damage and aging are somehow related. Several other pathologies associated with DNA repair defects, genetic instability and increased cancer risk are also discussed. In fact, studies with cells from these many syndromes have helped in understanding important levels of protection against cancer and aging, although little help has actually been conferred to the patients in terms of therapy. Finally, the recent advances in combined basic and translational research on DNA repair and chemotherapy are presented. FAPESP (Sao Paulo, Brazil) FAPESP (Sao Paulo, Brazil) CNPq (Brasilia, Brazil) CNPq (Brasilia, Brazil) |
Identificador |
FRONTIERS IN BIOSCIENCE-LANDMARK, IRVINE, v. 17, n. 7, supl. 4, Part 1, pp. 1362-1388, 36892, 2012 1093-9946 http://www.producao.usp.br/handle/BDPI/35455 10.2741/3992 |
Idioma(s) |
eng |
Publicador |
FRONTIERS IN BIOSCIENCE INC IRVINE |
Relação |
FRONTIERS IN BIOSCIENCE-LANDMARK |
Direitos |
restrictedAccess Copyright FRONTIERS IN BIOSCIENCE INC |
Palavras-Chave | #CANCER #XERODERMA PIGMENTOSUM #DNA REPAIR #FANCONI ANEMIA #ATAXIA TELANGIECTASIA #GENOMIC INSTABILITY SYNDROMES #CHEMOTHERAPY #NUCLEOTIDE EXCISION REPAIR #REVIEW #NUCLEOTIDE-EXCISION-REPAIR #NONPOLYPOSIS COLON-CANCER #STRAND-BREAK REPAIR #FANCONI-ANEMIA PROTEINS #INTERSTRAND CROSS-LINKS #TEMOZOLOMIDE PLUS O-6-BENZYLGUANINE #ATAXIA TELANGIECTASIA FIBROBLASTS #XERODERMA-PIGMENTOSUM VARIANT #TRANSCRIPTION-COUPLED REPAIR #RECURRENT MALIGNANT GLIOMA #BIOCHEMISTRY & MOLECULAR BIOLOGY #CELL BIOLOGY |
Tipo |
article original article publishedVersion |