DNA repair mechanisms protect our genome from carcinogenesis


Autoria(s): Strano Moraes, Maria Carolina; Cabral Neto, Januario Bispo; Menck, Carlos Frederico Martins
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

22/10/2013

22/10/2013

2012

Resumo

Human cells are constantly exposed to DNA damage. Without repair, damage can result in genetic instability and eventually cancer. The strong association between the lack of DNA damage repair, mutations and cancer is dramatically demonstrated by a number of cancer-prone human syndromes, such as xeroderma pigmentosum (XP), ataxia-telangiectasia (AT) and Fanconi anemia (FA). This review focuses on the historical discoveries related with these three diseases and describes their impact on the understanding of DNA repair mechanisms and the causes of human cancer. As deficiencies in DNA repair are also often related with progeria symptoms, unrepaired damage and aging are somehow related. Several other pathologies associated with DNA repair defects, genetic instability and increased cancer risk are also discussed. In fact, studies with cells from these many syndromes have helped in understanding important levels of protection against cancer and aging, although little help has actually been conferred to the patients in terms of therapy. Finally, the recent advances in combined basic and translational research on DNA repair and chemotherapy are presented.

FAPESP (Sao Paulo, Brazil)

FAPESP (Sao Paulo, Brazil)

CNPq (Brasilia, Brazil)

CNPq (Brasilia, Brazil)

Identificador

FRONTIERS IN BIOSCIENCE-LANDMARK, IRVINE, v. 17, n. 7, supl. 4, Part 1, pp. 1362-1388, 36892, 2012

1093-9946

http://www.producao.usp.br/handle/BDPI/35455

10.2741/3992

http://dx.doi.org/10.2741/3992

Idioma(s)

eng

Publicador

FRONTIERS IN BIOSCIENCE INC

IRVINE

Relação

FRONTIERS IN BIOSCIENCE-LANDMARK

Direitos

restrictedAccess

Copyright FRONTIERS IN BIOSCIENCE INC

Palavras-Chave #CANCER #XERODERMA PIGMENTOSUM #DNA REPAIR #FANCONI ANEMIA #ATAXIA TELANGIECTASIA #GENOMIC INSTABILITY SYNDROMES #CHEMOTHERAPY #NUCLEOTIDE EXCISION REPAIR #REVIEW #NUCLEOTIDE-EXCISION-REPAIR #NONPOLYPOSIS COLON-CANCER #STRAND-BREAK REPAIR #FANCONI-ANEMIA PROTEINS #INTERSTRAND CROSS-LINKS #TEMOZOLOMIDE PLUS O-6-BENZYLGUANINE #ATAXIA TELANGIECTASIA FIBROBLASTS #XERODERMA-PIGMENTOSUM VARIANT #TRANSCRIPTION-COUPLED REPAIR #RECURRENT MALIGNANT GLIOMA #BIOCHEMISTRY & MOLECULAR BIOLOGY #CELL BIOLOGY
Tipo

article

original article

publishedVersion