LIQUID-PHASE MICROEXTRACTION FOR SIMULTANEOUS CHROMATOGRAPHIC ANALYSIS OF THREE ANTIDEPRESSANT DRUGS IN PLASMA
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
14/10/2013
14/10/2013
2012
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| Resumo |
A method using Liquid Phase Microextraction for simultaneous detection of citalopram (CIT), paroxetine (PAR) and fluoxetine (FLU), using venlafaxine as internal standard, in plasma by high performance liquid chromatography with fluorescence detection was developed. The linearity was evaluated between 5.0 and 500 ng mL(-1) (r > 0.99) and the limit of quantification was 2.0, 3.0 and 5.0 ng mL-1 for CIT. PAR and FLU, respectively. Therefore, it can be applied to therapeutic drug monitoring, pharmacokinetics or bioavailability studies and its advantages are that it necessary relatively inexpensive equipment and sample preparation techniques. National Council for Scientific and Technological Development (CNPq), Brazil National Council for Scientific and Technological Development (CNPq)/Brazil Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)/Brazil [CDS-PPM-00055-09] Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG), Brazil |
| Identificador |
QUIMICA NOVA, SAO PAULO, v. 35, n. 1, supl. 1, Part 1-2, pp. 72-76, SEP, 2012 0100-4042 http://www.producao.usp.br/handle/BDPI/35018 10.1590/S0100-40422012000100014 |
| Idioma(s) |
eng |
| Publicador |
SOC BRASILEIRA QUIMICA SAO PAULO |
| Relação |
QUIMICA NOVA |
| Direitos |
openAccess Copyright SOC BRASILEIRA QUIMICA |
| Palavras-Chave | #LPME #ANTIDEPRESSANTS #HPLC-FL #SEROTONIN REUPTAKE INHIBITORS #NORFLUOXETINE ENANTIOMERS #CAPILLARY-ELECTROPHORESIS #SAMPLE PREPARATION #EXTRACTION #FLUOXETINE #WATER #ENRICHMENT #VOLUMES #ASSAY #CHEMISTRY, MULTIDISCIPLINARY |
| Tipo |
article original article publishedVersion |
