Does orchiectomy enhance the immune-stimulatory effects of melatonin during experimental Chagas' disease?
| Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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| Data(s) |
14/10/2013
14/10/2013
2012
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| Resumo |
Melatonin has been reported to play a fundamental role in T-cell immunoregulation. Control of Trypanosome cruzi parasitism during the acute phase of infection is considered to be critically dependent on direct macrophage activation by cytokines. The aim of this work was to evaluate the influence of exogenous melatonin treatment and the influences exerted by sexual hormones during the acute phase of the experimental Chagas' disease in rats. With melatonin treatment, orchiectomized animals (CMOR and IMOR) displayed the highest concentrations of IFN-gamma and TNF-alpha. On the 7th day post-infection, untreated and treated orchiectomized animals (IOR and IMOR) showed an enhanced number of peritoneal macrophages. Nitric oxide levels were also increased in untreated and treated orchiectomized (IOR and IMOR) when compared to the other groups, with or without LPS. Our data suggest that melatonin therapy associated with orchiectomy induced a stimulating effect on the immune response to the parasite. (c) 2012 Published by Elsevier Ltd. CAPES CAPES FAPESP FAPESP |
| Identificador |
RESEARCH IN VETERINARY SCIENCE, OXFORD, v. 93, n. 2, supl., Part 3, pp. 819-825, OCT, 2012 0034-5288 http://www.producao.usp.br/handle/BDPI/34570 10.1016/j.rvsc.2011.09.019 |
| Idioma(s) |
eng |
| Publicador |
ELSEVIER SCI LTD OXFORD |
| Relação |
RESEARCH IN VETERINARY SCIENCE |
| Direitos |
closedAccess Copyright ELSEVIER SCI LTD |
| Palavras-Chave | #CHAGAS'DISEASE #IFN-GAMMA #MELATONIN #ORCHIECTOMY #TNF-ALPHA #TRYPANOSOMA CRUZI #TRYPANOSOMA-CRUZI INFECTION #NITRIC-OXIDE PRODUCTION #CALOMYS-CALLOSUS #IFN-GAMMA #GONADAL-HORMONES #CELL BIOLOGY #SEX STEROIDS #PINEAL-GLAND #Y STRAIN #T-CELLS #VETERINARY SCIENCES |
| Tipo |
article original article publishedVersion |
