Dasatinib Overrides Imatinib Resistance Mediated by the F359I Residue Mutation in Two Patients with Chronic Myeloid Leukemia


Autoria(s): Serpa, Mariana; Sanabani, Sabri S.; Dorlhiac-Llacer, Pedro Enrique; Nardinelli, Luciana; Ferreira, Patricia de Barros; Borges Martins, Thays Fernanda; Seguro, Fernanda; Bendit, Israel
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

14/10/2013

14/10/2013

2012

Resumo

Despite the beneficial effects of imatinib mesylate, some patients may either not respond or respond suboptimally. Here, we report two chronic myelogenous leukemia patients; one had a suboptimal response according to European LeukemiaNet criteria (a major molecular response was not achieved after 18 months of standard-dose imatinib therapy) and the other had failure with a standard dose of imatinib. At the time of the suboptimal response in patient 1 and the failure in patient 2, we were able to detect the F359I mutation in the BCR-ABL tyrosine kinase domain using DNA sequencing in both patients. Therefore, it was decided to change the therapeutic regimen to dasatinib at a dose of 100 mg once daily in both patients. This change resulted in the achievement of complete cytogenetic remission in patient 1 after 4 months and a major molecular response within 2 and 3 months in both patients. Detection of the F359I mutation in our two cases likely explains the suboptimal response to imatinib in case 1 and the failure in case 2. This implies that in such cases dasatinib should be considered to effectively suppress the mutated clones. Copyright (C) 2011 S. Karger AG, Basel

Fundacao Maria Cecilia Souto Vidigal

Fundacao Maria Cecilia Souto Vidigal

Identificador

ACTA HAEMATOLOGICA, BASEL, v. 127, n. 1, supl. 1, Part 3, pp. 56-59, MAY, 2012

0001-5792

http://www.producao.usp.br/handle/BDPI/34309

10.1159/000333092

http://dx.doi.org/10.1159/000333092

Idioma(s)

eng

Publicador

KARGER

BASEL

Relação

ACTA HAEMATOLOGICA

Direitos

restrictedAccess

Copyright KARGER

Palavras-Chave #BCR-ABL KINASE #CHRONIC MYELOGENOUS LEUKEMIA #F359I POINT MUTATION #KINASE INHIBITORS #SUBOPTIMAL RESPONSE #BCR-ABL ONCOGENE #CHRONIC MYELOGENOUS LEUKEMIA #KINASE DOMAIN MUTATIONS #PHILADELPHIA-CHROMOSOME #TRANSFORMATION #MECHANISMS #GENE #HEMATOLOGY
Tipo

article

original article

publishedVersion