Cyclopropane- and spirolimonoids and related compounds from Hortia oreadica

The dichloromethane extract from taproots of Hortia oreadica afforded six limonoids, these are 9,11-dehydro-12 alpha-acetoxyhortiolide A, hortiolide C, 11 alpha-acetoxy-15-deoxy-6-hydroxyhortiolide C, hortiolide D, hortiolide E, 12 beta-hydroxyhortiolide E, in addition to the known limonoid, guyanin. The dichloromethane extract from stems of H. oreadica also afforded two limonoids 9,11-dehydro12 alpha-hydroxyhortiolide A and 6-hydroxyhortiolide C. As a result of this study and literature data, Hortia has been shown to produce highly specialized limonoids that are similar to those from the Flindersia (Flindersioideae). The taxonomy of Hortia has been debatable, with most authors placing it in the Toddalioideae. Considering the complexity of the isolated limonoids, Hortia does not show any close affinity to the genera of Toddalioideae. That is, the limonoids appear to be of little value in resolving the taxonomic situation of Hortia. (C) 2012 Elsevier Ltd. All rights reserved.

Institutos Nacionais de Ciencia e Tecnologia, do Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq/MCT)

CNPq/MCT (Institutos Nacionais de Ciencia e Tecnologia, do Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

CAPES (Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior)

Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)

Financiadora de Estudos e Projetos (FINEP)

Financiadora de Estudos e Projetos (FINEP)