Effects of repetitive transcranial magnetic stimulation on clinical, social, and cognitive performance in postpartum depression


Autoria(s): Myczkowski, Martin Luiz; Dias, Alvaro Machado; Luvisotto, Tatiana; Arnaut, Debora; Bellini, Bianca Boura; Mansur, Carlos Gustavo; Renno, Joel; Tortella, Gabriel; Ribeiro, Philip Leite; Marcolin, Marco Antonio
Contribuinte(s)

UNIVERSIDADE DE SÃO PAULO

Data(s)

02/10/2013

02/10/2013

25/10/2012

Resumo

Background: This randomized, placebo-controlled, double-blind pilot study evaluated the impact of repetitive transcranial magnetic stimulation (rTMS) on clinical, cognitive, and social performance in women suffering with postpartum depression. Methods: Fourteen patients were randomized to receive 20 sessions of sham rTMS or active 5 Hz rTMS over the left dorsolateral prefrontal cortex. Psychiatric clinical scales and a neuropsychological battery were applied at baseline (pretreatment), week 4 (end of treatment), and week 6 (follow-up, posttreatment week 2). Results: The active rTMS group showed significant improvement 2 weeks after the end of rTMS treatment (week 6) in Hamilton Depression Rating Scale (P = 0.020), Global Assessment Scale (P = 0.037), Clinical Global Impression (P = 0.047), and Social Adjustment Scale-Self Report-Work at Home (P = 0.020). Conclusion: This study suggests that rTMS has the potential to improve the clinical condition in postpartum depression, while producing marginal gains in social and cognitive function.

Identificador

NEUROPSYCHIATRIC DISEASE AND TREATMENT, ALBANY, v. 8, pp. 491-500, OUT-25, 2012

1176-6328

http://www.producao.usp.br/handle/BDPI/33964

10.2147/NDT.S33851

http://dx.doi.org/10.2147/NDT.S33851

Idioma(s)

eng

Publicador

DOVE MEDICAL PRESS LTD

ALBANY

Relação

NEUROPSYCHIATRIC DISEASE AND TREATMENT

Direitos

openAccess

Copyright DOVE MEDICAL PRESS LTD

Palavras-Chave #TRANSCRANIAL MAGNETIC STIMULATION #POSTPARTUM DEPRESSION #CLINICAL PERFORMANCE #COGNITIVE PERFORMANCE #SOCIAL PERFORMANCE #DORSOLATERAL PREFRONTAL CORTEX #RANDOMIZED CONTROLLED-TRIAL #INFANT DEVELOPMENT #PREGNANCY #BRAIN #SYMPTOMS #DISORDER #MOTHERS #RISK #PSYCHOPATHOLOGY #CLINICAL NEUROLOGY #PSYCHIATRY
Tipo

article

original article

publishedVersion