Correlation of photodynamic activity and singlet oxygen quantum yields in two series of hydrophobic monocationic porphyrins
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
---|---|
Data(s) |
24/09/2013
24/09/2013
01/01/2012
|
Resumo |
The photodynamic properties of eight hydrophobic monocationic methyl and ruthenium polypyridine complex derivatives of free-base and zinc(II) meso-triphenyl-monopyridylporphyrin series were evaluated and compared using HeLa cells as model. The cream-like polymeric nanocapsule formulations of marine atelocollagen/xanthan gum, prepared by the coacervation method, exhibited high phototoxicity but negligible cytotoxicity in the dark. Interestingly, the formulations of a given series presented similar photodynamic activities but the methylated free-base derivatives were significantly more phototoxic than the respective ruthenated photosensitizers, reflecting the higher photoinduced singlet oxygen quantum yields of those monocationic porphyrin dyes. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) |
Identificador |
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES, HACKENSACK, v. 16, n. 1, pp. 55-63, JAN, 2012 1088-4246 http://www.producao.usp.br/handle/BDPI/33647 10.1142/S1088424611004336 |
Idioma(s) |
eng |
Publicador |
WORLD SCI PUBL CO INC HACKENSACK |
Relação |
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES |
Direitos |
restrictedAccess Copyright WORLD SCI PUBL CO INC |
Palavras-Chave | #CATIONIC PORPHYRINS #POLYMERIC ENCAPSULATION #PDT #HELA CELLS #OF-THE-ART #PHOTOPHYSICAL PROPERTIES #THERAPY #PHOTOSENSITIZERS #DELIVERY #STATE #COACERVATION #PRINCIPLES #VEHICLES #POLYMER #CHEMISTRY, MULTIDISCIPLINARY |
Tipo |
article original article publishedVersion |