Common matrix metalloproteinase 2 gene haplotypes may modulate left ventricular remodelling in hypertensive patients
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/08/2013
20/08/2013
01/03/2012
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Resumo |
Matrix metalloproteinases (MMPs) are involved in cardiac remodelling. We examined whether MMP-2 genetic polymorphisms are associated with hypertension and left ventricular (LV) remodelling in hypertensive patients. We studied 160 hypertensive patients and 123 healthy controls. Echocardiography was performed in all patients and the C-1306T (rs243865) and C-735T (rs 2285053) MMP-2 polymorphisms were analysed. Haplo.stats analysis was used to evaluate whether MMP-2 haplotypes are associated with hypertension and with extremes in LV mass index (LVMI). Multiple linear regression analysis was performed to assess whether MMP-2 genotypes or haplotypes affect LVMI and other echocardiography parameters. The C-1306T 'CC' genotype was associated with reduced LVMI and LV end-diastolic diameter (EDD) (P=0.0365 and P=0.0438, respectively). The haplotype 'C, C' was associated with reduced LVMI and EDD (P=0.0278 and P=0.0322, respectively). The comparison of upper and lower extremes of the LVMI phenotype showed that the 'C, C' haplotype was more common in the lower LVMI group (P=0.0060), whereas the 'T, C' haplotype was more common in the higher quartile of LVMI (P=0.0187), and this haplotype was associated with increased risk of higher LVMI values (odds ratio=3.5121, 95% confidence interval 1.3193-9.3494). The findings suggest that MMP-2 polymorphisms affect hypertension-induced LV remodelling. Journal of Human Hypertension (2012) 26, 171-177; doi:10.1038/jhh.2011.8; published online 10 February 2011 Fundacao de Amparo a Pesquisa do Estado de Sao Paulo Fundacao de Amparo a Pesquisa do Estado de Sao Paulo Conselho Nacional de Desenvolvimento Cientifico e Tecnologico Conselho Nacional de Desenvolvimento Cientifico e Tecnologico Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior Coordenadoria de Aperfeicoamento de Pessoal de Nivel Superior |
Identificador |
JOURNAL OF HUMAN HYPERTENSION, LONDON, v. 26, n. 3, pp. 171-177, MAR, 2012 0950-9240 http://www.producao.usp.br/handle/BDPI/32636 10.1038/jhh.2011.8 |
Idioma(s) |
eng |
Publicador |
NATURE PUBLISHING GROUP LONDON |
Relação |
JOURNAL OF HUMAN HYPERTENSION |
Direitos |
restrictedAccess COPYRIGHT 2012 Macmillan Publishers Limited All rights reserved 0950-9240/12 |
Palavras-Chave | #LEFT VENTRICULAR HYPERTROPHY #MMP-2 POLYMORPHISMS #HEART REMODELLING #MMP-2 HAPLOTYPES #HEART-FAILURE #VASCULAR DYSFUNCTION #POLYMORPHISMS #HYPERTROPHY #INHIBITORS #MMP-9 #MATRIX-METALLOPROTEINASE-2 #MYOCARDIUM #VARIANTS #SURVIVAL #PERIPHERAL VASCULAR DISEASE |
Tipo |
article original article publishedVersion |