Potential of Bioactive Glass Particles of Different Size Ranges to Affect Bone Formation in Interproximal Periodontal Defects in Dogs
Contribuinte(s) |
UNIVERSIDADE DE SÃO PAULO |
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Data(s) |
20/10/2012
20/10/2012
2009
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Resumo |
Background: The aim of this study was to compare the potential of bioactive glass particles of different size ranges to affect bone formation in periodontal defects, using the guided tissue regeneration model in dogs. Methods: In six dogs, 2-wall intrabony periodontal defects were surgically created and chronified on the mesial surfaces of mandibular third premolars and first molars bilaterally. After 1 month, each defect was randomly assigned to treatment with bioabsorbable membrane in association with bioactive glass with particle sizes between 300 and 355 mu m (group 1) or between 90 and 710 mu m (group 2), membrane alone (group 3), or negative control (group 4). The dogs were sacrificed 12 weeks after surgeries, and histomorphometric measurements were made of the areas of newly formed bone, new mineralized bone, and bioactive glass particle remnants. Results: With regard to the area of bioactive glass particle remnants, there was a statistically significant difference between groups 1 and 2, favoring group 1. There were greater areas of mineralized bone in groups 1 and 2 compared to groups 3 and 4 (P<0.05). Conclusion: The bioactive glass particles of small size range underwent faster resorption and substitution by new bone than the larger particles, and the use of bioactive glass particles favored the formation of mineralized bone. J Periodontol 2009;80:808-815. |
Identificador |
JOURNAL OF PERIODONTOLOGY, v.80, n.5, p.808-815, 2009 0022-3492 http://producao.usp.br/handle/BDPI/32168 10.1902/jop.2009.080583 |
Idioma(s) |
eng |
Publicador |
AMER ACAD PERIODONTOLOGY |
Relação |
Journal of Periodontology |
Direitos |
restrictedAccess Copyright AMER ACAD PERIODONTOLOGY |
Palavras-Chave | #Bone regeneration #case-comparison studies #glass #grafts #membranes #guided tissue regeneration #GUIDED TISSUE REGENERATION #GENERALIZED AGGRESSIVE PERIODONTITIS #FREEZE-DRIED BONE #INTRABONY DEFECTS #BIOABSORBABLE MEMBRANE #HEALING RESPONSE #IMPLANTATION #ATTACHMENT #GRAFTS #Dentistry, Oral Surgery & Medicine |
Tipo |
article original article publishedVersion |