Piperacillin/tazobactam-induced neurotoxicity in a hemodialysis patient: a case report
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
---|---|
Data(s) |
01/04/2016
01/04/2016
2015
|
Resumo |
Antibiotics are potentially a cause of neurotoxicity in dialysis patients, the most common are thebeta-lactams as ceftazidime and cefepime, and few cases have been reported after piperacillin/tazobactam use. This report presents a case of a hypertensive and diabetic 67-year-old woman inregular hemodialysis, which previously had a stroke. She was hospitalized presenting pneumonia,which was initially treated with cefepime. Two days after treatment, she presented dysarthria, lefthemiparesis, ataxia, and IX and X cranial nerves paresis. Computed tomography showed no acutelesions and cefepime neurotoxicity was hypothesized, and the antibiotic was replaced bypiperacillin/tazobactam. The neurologic signs disappeared; however, 4 days after with piperacillin/tazobactam treatment, the neurological manifestations returned. A new computed tomographyshowed no new lesions, and the second antibiotic regimen withdrawn. After two hemodialysissessions, the patient completely recovered from neurological manifestations. The patient presentedsequentially neurotoxicity caused by two beta-lactams antibiotics. This report meant to alertclinicians that these antibiotics have dangerous neurological effects in chronic kidney diseasepatients. |
Formato |
143-145 |
Identificador |
http://dx.doi.org/10.1111/hdi.12194 Hemodialysis International, v. 19, n. 1, p. 143-145, 2015. 1492-7535 http://hdl.handle.net/11449/136852 10.1111/hdi.12194 6958241665808406 1893658424829647 6946495726565059 5559543779752320 2107710565827429 |
Idioma(s) |
eng |
Relação |
Hemodialysis International |
Direitos |
closedAccess |
Palavras-Chave | #Chronic kidney disease #Hemodialysis #Neurotoxicity #Piperacillin/tazobactam |
Tipo |
info:eu-repo/semantics/article |