Piperacillin/tazobactam-induced neurotoxicity in a hemodialysis patient: a case report


Autoria(s): Neves, Precil Diego Miranda de Menezes; Freitas, Fernanda Moreira de; Kojima, Christiane Akemi; Carmello, Beatriz Leone; Bazan, Rodrigo; Barretti, Pasqual; Martin, Luis Cuadrado
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

01/04/2016

01/04/2016

2015

Resumo

Antibiotics are potentially a cause of neurotoxicity in dialysis patients, the most common are thebeta-lactams as ceftazidime and cefepime, and few cases have been reported after piperacillin/tazobactam use. This report presents a case of a hypertensive and diabetic 67-year-old woman inregular hemodialysis, which previously had a stroke. She was hospitalized presenting pneumonia,which was initially treated with cefepime. Two days after treatment, she presented dysarthria, lefthemiparesis, ataxia, and IX and X cranial nerves paresis. Computed tomography showed no acutelesions and cefepime neurotoxicity was hypothesized, and the antibiotic was replaced bypiperacillin/tazobactam. The neurologic signs disappeared; however, 4 days after with piperacillin/tazobactam treatment, the neurological manifestations returned. A new computed tomographyshowed no new lesions, and the second antibiotic regimen withdrawn. After two hemodialysissessions, the patient completely recovered from neurological manifestations. The patient presentedsequentially neurotoxicity caused by two beta-lactams antibiotics. This report meant to alertclinicians that these antibiotics have dangerous neurological effects in chronic kidney diseasepatients.

Formato

143-145

Identificador

http://dx.doi.org/10.1111/hdi.12194

Hemodialysis International, v. 19, n. 1, p. 143-145, 2015.

1492-7535

http://hdl.handle.net/11449/136852

10.1111/hdi.12194

6958241665808406

1893658424829647

6946495726565059

5559543779752320

2107710565827429

Idioma(s)

eng

Relação

Hemodialysis International

Direitos

closedAccess

Palavras-Chave #Chronic kidney disease #Hemodialysis #Neurotoxicity #Piperacillin/tazobactam
Tipo

info:eu-repo/semantics/article