Validation of cefazolin sodium by UV-spectrophotometric method

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

A simple, fast and reproducible UV Spectrophotometric method was developed and validated for quantification of cefazolin sodium in pharmaceutical form powder for injectable solution, the method proved effective, easy applicability, low cost, besides it does not generate toxic wastes to the operator and the environment, corroborating with the routine analysis of quality control to ensure the therapeutic efficacy of the drug already marketed. The method presented being capable to detect and quantify the drug obtaining satisfactory results regarding specificity, precision, accuracy and robustness, linear range of 8 to 28 µg/mL, showing correlation coefficient of 0.9999 when analyzed in the wavelenght λ=270 nm spectrophotometer.