Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
28/01/2016
28/01/2016
2012
|
| Resumo |
Coordenação de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 2008/10390-2 Processo FAPESP: 2009/06499-1 We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms. |
| Formato |
281-288 |
| Identificador |
http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15 Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012. 2028-3997 http://hdl.handle.net/11449/133718 10.13171/mjc.1.6.2012.02.05.15 ISSN2028-3997-2012-01-06-281-288.pdf 9818597076971227 2114570774349859 |
| Idioma(s) |
eng |
| Relação |
Mediterranean Journal of Chemistry |
| Direitos |
openAccess |
| Palavras-Chave | #Carbohydrate #Glycoconjugates #1,2,3-triazole #Antitubercular activity |
| Tipo |
info:eu-repo/semantics/article |
