Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
07/12/2015
07/12/2015
15/08/2015
|
| Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Processo FAPESP: 2010/52327-5 Processo FAPESP: 2010/16732-2 Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi. |
| Formato |
3342-3345 |
| Identificador |
http://dx.doi.org/10.1016/j.bmcl.2015.05.072 Bioorganic and Medicinal Chemistry Letters, v. 25, n. 16, p. 3342-3345, 2015. 1464-3405 http://hdl.handle.net/11449/131525 10.1016/j.bmcl.2015.05.072 26055530 |
| Idioma(s) |
eng |
| Publicador |
Elsevier B. V. |
| Relação |
Bioorganic and Medicinal Chemistry Letters |
| Direitos |
closedAccess |
| Palavras-Chave | #Drug discovery #Leishmania amazonensis #Leishmania infantum #Leishmanicidal activity #Prenylated chalcone #Trypanocidal activity #Trypanosoma cruzi |
| Tipo |
info:eu-repo/semantics/article |
