Acute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats


Autoria(s): Traesel, Giseli Karenina; Souza, Juliane Coelho de; Barros, Aline Lima de; Souza, Marcos Alexandre; Schmitz, Wanderley Onofre; Muzzi, Rozanna Marques; Oesterreich, Silvia Aparecida; Arena, Arielle Cristina
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

03/11/2015

03/11/2015

01/12/2014

Resumo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Processo FAPESP: 2013/01802-3

Acrocomia aculeata, popularly known as "bocaitiva", is a species used for nutritional purposes and for the treatment of various diseases, as it has, among other things, high levels of antioxidant compounds. This study aimed to assess the toxicological profile of A. aculeata, through acute and subacute toxicity tests. Male and female rats (Wistar) received by gavage 2000 mg/kg of oil extracted from the pulp of A. aculeata (OPAC) for the acute toxicity test and 125, 250, 500 or 1000 mg/kg of OPAC for subacute toxicity test. In the acute toxicity study no mortality or behavioral changes were observed in rats treated with 2000 mg/kg, indicating that the LD50 is higher than this dose. In the subacute toxicity test, the tested doses produced no significant changes in hematological, biochemical or histopathological parameters in the animals exposed. These results demonstrate the absence of acute and subacute toxicity after oral exposure to A. aculeata oil in rats. However, further studies in animals and in humans are needed in order to have sufficient safety evidence for its use in humans. (C) 2014 Elsevier Ltd. All rights reserved.

Formato

320-325

Identificador

http://www.sciencedirect.com/science/article/pii/S0278691514004554

Food And Chemical Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 74, p. 320-325, 2014.

0278-6915

http://hdl.handle.net/11449/129973

http://dx.doi.org/10.1016/j.fct.2014.10.026

WOS:000347274600042

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Food And Chemical Toxicology

Direitos

closedAccess

Palavras-Chave #Acrocomia aculeata #Acute toxicity #Subacute toxicity #Safety #Rats
Tipo

info:eu-repo/semantics/article