Coupling of respiratory and sympathetic activities in rats submitted to chronic intermittent hypoxia


Autoria(s): Moraes, Davi José de Almeida; Machado, Benedito Honório; Zoccal, Daniel Breseghello
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

03/11/2015

03/11/2015

01/01/2014

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

The respiratory modulation of sympathetic activity relies on the balance between excitatory and inhibitory inputs from the brainstem respiratory network to presympathetic neurons of the rostral ventrolateral medulla. This central respiratory-sympathetic contributes for the generation of respiratory-related rhythmical oscillations in heart rate and arterial pressure levels, whose functional effects on the blood gas exchange/perfusion and cardiac work remain to be elucidated. Herein, we discuss the experimental evidence describing the potential neural mechanisms underlying the entrainment between respiratory and sympathetic activities at baseline conditions as well as under conditions of metabolic challenges. We also discuss the possible implications of changes in the strength or pattern of the central respiratory-sympathetic coupling in the genesis of sympathetic overactivity and neurogenic hypertension, including that associated with the exposure to chronic intermittent hypoxia.

Formato

25-38

Identificador

http://www.sciencedirect.com/science/article/pii/B9780444634887000021

Breathing, Emotion And Evolution. Amsterdam: Elsevier Science Bv, v. 212, p. 25-38, 2014.

0079-6123

http://hdl.handle.net/11449/129953

http://dx.doi.org/10.1016/B978-0-444-63488-7.00002-1

WOS:000349339500003

Idioma(s)

eng

Publicador

Elsevier B.V.

Relação

Breathing, Emotion And Evolution

Direitos

closedAccess

Palavras-Chave #Sympathetic activity #Respiratory pattern #Hypercapnia #Hypoxia #Hypertension
Tipo

info:eu-repo/semantics/review