Hydroxyapatite and a new fibrin sealant derived from snake venom as scaffold to treatment of cranial defects in rats
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
21/10/2015
21/10/2015
01/01/2015
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Processo FAPESP: 2012/02689-3 Processo FAPESP: 2009/53846-9 Processo FAPESP: 2009/06280-0 Processo FAPESP: 2012/08101-8 Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair. |
Formato |
196-203 |
Identificador |
http://www.scielo.br/scielo.php?pid=S1516-14392015000100196&script=sci_arttext Materials Research-ibero-american Journal Of Materials, v. 18, n. 1, p. 196-203, 2015. 1516-1439 http://hdl.handle.net/11449/129396 http://dx.doi.org/10.1590/1516-1439.316014 S1516-14392015000100196 WOS:000353061100026 S1516-14392015000100196.pdf |
Idioma(s) |
eng |
Publicador |
Univ Fed Sao Carlos, Dept Engenharia Materials |
Relação |
Materials Research-ibero-american Journal Of Materials |
Direitos |
openAccess |
Palavras-Chave | #Bioceramic #Fibrin sealant #Bone regeneration |
Tipo |
info:eu-repo/semantics/article |