Anti-androgenic activities of diuron and its metabolites in male Nile tilapia (Oreochromis niloticus)
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
21/10/2015
21/10/2015
01/07/2015
|
Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Processo FAPESP: 2011/52061-8 Diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) is a widely used herbicide which has been frequently detected in surface waters throughout the world. In vivo bioassay guided fractionation studies indicated that diuron may have estrogenic activity augmented by biotransformation. This study evaluated the effects of diuron and three of its metabolites on plasma hormone concentrations and spermatogenesis of the freshwater fish Nile tilapia (Oreochromis niloticus). Sexually mature male fish were exposed for 25 days to diuron, as well to its metabolites 3,4-dichloroaniline (DCA), 3,4-dichlorophenylurea (DCPU) and 3,4-dichlorophenyl-N-methylurea (DCPMU), at concentrations of 200 ng/L. Testosterone levels were decreased by diuron, but had limited effects on gonadal histology. Diuron metabolites, however, caused significant decreases in testosterone and in 11-ketotestosterone, gonadosomatic index, diameter of seminiferous tubules and in the mean percentages of germ cells (spermatids and spermatozoa). We conclude that these metabolites have antiandrogenic activity to male Nile tilapia, potentially causing reproductive impairment in male fish. |
Formato |
10-15 |
Identificador |
http://www.sciencedirect.com/science/article/pii/S0166445X15001198 Aquatic Toxicology. Amsterdam: Elsevier Science Bv, v. 164, p. 10-15, 2015. 0166-445X http://hdl.handle.net/11449/128886 http://dx.doi.org/10.1016/j.aquatox.2015.04.013 WOS:000356739200002 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
Aquatic Toxicology |
Direitos |
closedAccess |
Palavras-Chave | #Nile tilapia #Gametogenesis #Diuron #Diuron metabolites #Andi-androgenic effects |
Tipo |
info:eu-repo/semantics/article |