NLRP1 L155H polymorphism is a risk factor for preeclampsia development
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
21/10/2015
21/10/2015
01/06/2015
|
| Resumo |
Problem: Augmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome'genes and preeclampsia. Method of study: Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia. Results and Conlclusions: The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR=1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder. |
| Formato |
577-581 |
| Identificador |
http://onlinelibrary.wiley.com/doi/10.1111/aji.12353/abstract American Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 73, n. 6, p. 577-581, 2015. 1046-7408 http://hdl.handle.net/11449/128571 http://dx.doi.org/10.1111/aji.12353 WOS:000354390000010 |
| Idioma(s) |
eng |
| Publicador |
Wiley-Blackwell |
| Relação |
American Journal Of Reproductive Immunology |
| Direitos |
closedAccess |
| Palavras-Chave | #IL-1 ss #Inflammasome #NLRP1 #Preeclampsia |
| Tipo |
info:eu-repo/semantics/article |
