Involvement of alpha(1B)-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
21/10/2015
21/10/2015
05/03/2015
|
Resumo |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo FAPESP: 08/50423-7 Imipramine is a tricyclic antidepressant inhibitor of norepinephrine and serotonin neuronal reuptake. The roles of specific alpha(1)-adrenoceptor subtypes that might be targeted by the increased synaptic levels of noradrenaline induced by imipramine are not well understood. This study investigates the alpha(1)-adrenoceptor subtypes involved in the anti-immobility effect of imipramine in the mouse tail suspension test. The antiimmobility effect of imipramine (32 mg/kg, i.p.) was significantly antagonised by the non-subtype-selective alpha(1)-adrenoceptor antagonist prazosin (0.5 and 1.0 mg/kg, i.p.). Neither the selective alpha(1A)-adrenoceptor antagonist 5-methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidineclione (RS-100329, 0.5 and 1.0 mg/kg) nor the selective alpha(1D)-adrenoceptor antagonist 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride, (BMY-7378, up to 1.0 mg/kg, i.p.) affected the anti-immobility effect of imipramine. However, the anti-immobility effect of imipramine was significantly antagonised by the selective alpha(1B)-adrenoceptor antagonist (2S)-4-(4-amino-6,7-dimethoxy-2quinazoliny1)-2-[[(1,1-dimethylethyl)aminolcarbonyl]-1-piperazinecarboxylate (L-765,314). In addition, mice treated only with RS-100329 or BMY-7378, but not with L-765,314, showed reduced immobility times in comparison to mice treated with vehicle. These results indicate that the selective antagonism of alpha(1A)- and alpha(1D)- adrenoceptors results in antidepressant-like effects and that the am-subtype is the main target for the increased levels of noradrenaline caused by imipramine. (C) 2015 Elsevier B.V. All rights reserved. |
Formato |
39-42 |
Identificador |
http://www.sciencedirect.com/science/article/pii/S0014299915000321 European Journal Of Pharmacology. Amsterdam: Elsevier Science Bv, v. 750, p. 39-42, 2015. 0014-2999 http://hdl.handle.net/11449/128566 http://dx.doi.org/10.1016/j.ejphar.2015.01.010 WOS:000350389200007 |
Idioma(s) |
eng |
Publicador |
Elsevier B.V. |
Relação |
European Journal Of Pharmacology |
Direitos |
closedAccess |
Palavras-Chave | #Alpha(1)-Adrenoceptors #Alpha(1B)-Adrenoceptor #Tricyclic antidepressants #Imipramine #Tail suspension test |
Tipo |
info:eu-repo/semantics/article |