Effects of a Mixture of Pesticides on the Adult Female Reproductive System of Sprague-Dawley, Wistar, and Lewis Rats


Autoria(s): Pascotto, Viviane M.; Guerra, Marina T.; Anselmo Franci, Janete Aparecida; Camargo, Joao Lauro V. de; Kempinas, Wilma G.; Franchi, Carla A. S.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

21/10/2015

21/10/2015

03/05/2015

Resumo

The Brazilian federal government Agency for Health Surveillance detected pesticide residues in fresh food available for consumers all over the country. The current study investigated the effects of a mixture of some of those pesticides (dichlorvos, dicofol, dieldrin, endosulfan, and permethrin) on the reproductive system of Sprague-Dawley (SD), Wistar (WT), and Lewis (LEW) rats. Female rats from each strain were randomized into three experimental groups and were fed a control diet or diets added with pesticides mixture at their respective no-observed-effect level (NOEL)/no-observed-adverse-effect level (NOAEL) (low dose) (mg/kg/d): dichlorvos (0.23), dicofol (0.5), dieldrin (0.025), endosulfan (0.7), permethrin (5), or lowest-observed-effect level (LOEL)/lowest-effect level (LEL)/ lowest-observed-adverse-effect level (LOAEL) (toxically effective dose) (mg/kg/d): dichlorvos (2.3), dicofol (2.1), dieldrin (0.05), endosulfan (3.8), and permethrin (25) as reported in the literature. Euthanasia was performed between wk 10 and 12, during the estrous stage. Decreased body weights gain (SD and WT) and increased liver weights (SD, WT, and LEW) were observed in each strain fed the pesticides mixture at the higher levels. At that dose level, rat strains also varied in their responses regarding the estrous cycle, hormonal levels, and number of developing ovarian follicles. The studied mixture of pesticides was found to interfere with the female reproductive system when individual pesticides were mixed above a certain level, indicating a threshold exists for each of the strains studied.

Formato

602-616

Identificador

http://www.tandfonline.com/doi/full/10.1080/15287394.2015.1010467#.VeC1vvlViko

Journal Of Toxicology And Environmental Health-part A-current Issues, v. 78, n. 9, p. 602-616, 2015.

1528-7394

http://hdl.handle.net/11449/128380

http://dx.doi.org/10.1080/15287394.2015.1010467

WOS:000354455900006

Idioma(s)

eng

Publicador

Taylor &francis Inc

Relação

Journal Of Toxicology And Environmental Health-part A-current Issues

Direitos

closedAccess

Tipo

info:eu-repo/semantics/article