Using the comet and micronucleus assays for genotoxicity studies: a review
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
21/08/2015
21/08/2015
2015
|
| Resumo |
Physical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these tests, the comet assay (CA) and micronucleus assay (MNA) are the most commonly used. However, there are different protocols and recommendations already published. This is the first review, after the inclusion of CA in S2R1 guidance and OECD 489, which summarizes the main technical recommendations of both CA and MNA. |
| Formato |
74-82 |
| Identificador |
Biomedicine & Pharmacotherapy, v. 72, p. 74-82, 2015. 0753-3322 http://hdl.handle.net/11449/127163 http://dx.doi.org/10.1016/j.biopha.2015.04.004 3892896473273324 |
| Idioma(s) |
eng |
| Relação |
Biomedicine & Pharmacotherapy |
| Direitos |
closedAccess |
| Palavras-Chave | #Genotoxicity tests #Comet assay #Micronucleus assay #Mutagenesis |
| Tipo |
info:eu-repo/semantics/article |
