Casearia sylvestris Swartz Extract Release Using Natural Rubber Latex Biomembranes as Carrier


Autoria(s): Borges, Felipe Azevedo; Trecco, Alberto; Miranda, Matheus Carlos Romeiro; Perri, Elaíse G.; Santos, André Gonzaga dos; Herculano, Rondinelli Donizetti; Barros, Natan Roberto
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

15/05/2015

15/05/2015

2014

Resumo

The Natural Rubber Latex (NRL) from Hevea brasiliensis has shown promise in biomedical applications due to its low cost, easy handling, mechanical properties and biocompatibility, being used for bone regeneration and wound healing due to its natural stimulus to angiogenesis. The aim of this work was to incorporate Casearia sylvestris Sw. extract in NRL biomembranes and study its release behavior. The complex membrane-extract has as object of study a new approach of using C. sylvestris extract in the treatment of wounds, for possessing antiseptic activity, anti-inflammatory and analgesic properties. The C. sylvestris species (Salicaceae), popularly known as "guaçatonga", presents great distribution and is used in folk medicine as antiulcer, wound healing, anti-snake venom, properties which have been proven and related to clerodane diterpenes (casearins A-X). The release rate of C. sylvestris compounds from extract-membrane complex was monitored and analyzed using the method of optical spectroscopy (UV-VIS). The release varied with temperature ranging from 14 to 33 days, releasing more than 90%, with an interesting and promising biomedical application, such as wound healing and burns.

Formato

1420-1430

Identificador

European Journal of Medicinal Plants, v. 4, n. 12, p. 1420-1430, 2014.

2231-0894

http://hdl.handle.net/11449/123623

http://dx.doi.org/10.9734/EJMP/2014/12039

5743408042753244

Idioma(s)

eng

Relação

European Journal of Medicinal Plants

Direitos

closedAccess

Palavras-Chave #Casearia sylvestris Swartz #Latex membrane #natural rubber
Tipo

info:eu-repo/semantics/article