Microbial transformations of Aryltetralone and Aryltetralin Lignans by Cunninghamella echinulata and Beauveria bassiana
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
15/05/2015
15/05/2015
2010
|
Resumo |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Microbiological transformation of the aryltetralone lignan (−)-8′-epi-aristoligone (1) with Cunninghamella echinulata ATCC 10028B afforded two known natural lignans, (−)-holostyligone (3) and (−)-arisantetralone (4). Incubation of the aryltetralin lignan (−)-isogalbulin (2), obtained by chemical transformation of 1, with C. echinulata ATCC 10028B afforded the known lignan aryltetralol (5) and seven new metabolites, (−)-8-hydroxyisogalbulin (6), (−)-7-methoxyisogalbulin (7), (−)-4′-O-demethyl-8-hydroxyisogalbulin (8), (−)-7-methoxy-8-hydroxyisogalbulin (9), (−)-4′-O-demethyl-7-methoxyisogalbulin (10), (−)-4′,5-O-didemethylcyclogalgravin (11), and (−)-4′-O-demethylcyclogalgravin (12). When 2 was subjected to biotransformation with Beauveria bassiana ATCC 7159, (−)-8-hydroxyisogalbulin (6) was the only isolable product. The structures of all new compounds were established by detailed analysis of their spectroscopic data. |
Formato |
1933-1937 |
Identificador |
Journal of Natural Products, v. 73, p. 1933-1937, 2010. 0163-3864 http://hdl.handle.net/11449/123580 http://dx.doi.org/10.1021/np100607s 5981353442037051 0364103051736128 |
Idioma(s) |
eng |
Relação |
Journal of Natural Products |
Direitos |
closedAccess |
Palavras-Chave | #Cunninghamella echinulata #Aristolochiaceae #lignanas #Holostylis reniformis #Beauveria bassiana |
Tipo |
info:eu-repo/semantics/article |