Evolutionary History of the PER3 Variable Number of Tandem Repeats (VNTR): Idiosyncratic Aspect of Primate Molecular Circadian Clock
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
18/03/2015
18/03/2015
15/09/2014
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Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The PER3 gene is one of the clock genes, which function in the core mammalian molecular circadian system. A variable number of tandem repeats (VNTR) locus in the 18th exon of this gene has been strongly associated to circadian rhythm phenotypes and sleep organization in humans, but it has not been identified in other mammals except primates. To better understand the evolution and the placement of the PER3 VNTR in a phylogenetical context, the present study enlarges the investigation about the presence and the structure of this variable region in a large sample of primate species and other mammals. The analysis of the results has revealed that the PER3 VNTR occurs exclusively in simiiforme primates and that the number of copies of the primitive unit ranges from 2 to 11 across different primate species. Two transposable elements surrounding the 18th exon of PER3 were found in primates with published genome sequences, including the tarsiiforme Tarsius syrichta, which lacks the VNTR. These results suggest that this VNTR may have evolved in a common ancestor of the simiiforme branch and that the evolutionary copy number differentiation of this VNTR may be associated with primate simiiformes sleep and circadian phenotype patterns. |
Formato |
6 |
Identificador |
http://dx.doi.org/10.1371/journal.pone.0107198 Plos One. San Francisco: Public Library Science, v. 9, n. 9, 6 p., 2014. 1932-6203 http://hdl.handle.net/11449/117409 10.1371/journal.pone.0107198 WOS:000341774800046 WOS000341774800046.pdf |
Idioma(s) |
eng |
Publicador |
Public Library Science |
Relação |
Plos One |
Direitos |
openAccess |
Tipo |
info:eu-repo/semantics/article |