Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: Isolation, characterization, conformational studies and biological activity
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
18/03/2015
18/03/2015
01/11/2014
|
| Resumo |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) A cyclic peptide, jatrophidin I, was isolated from the latex of Jatropha curcas L. Its structure was elucidated by extensive 2D NMR spectroscopic analysis, with additional conformational studies performed using Molecular Dynamics/Simulated Annealing (MD/SA). Jatrophidin I had moderate protease inhibition activity when compared with pepstatin A; however, the peptide was inactive in antimalarial, cytotoxic and antioxidant assays. (C) 2014 Elsevier Ltd. All rights reserved. |
| Formato |
91-96 |
| Identificador |
http://dx.doi.org/10.1016/j.phytochem.2014.08.006 Phytochemistry. Oxford: Pergamon-elsevier Science Ltd, v. 107, p. 91-96, 2014. 0031-9422 http://hdl.handle.net/11449/116707 10.1016/j.phytochem.2014.08.006 WOS:000343840500010 |
| Idioma(s) |
eng |
| Publicador |
Elsevier B.V. |
| Relação |
Phytochemistry |
| Direitos |
closedAccess |
| Palavras-Chave | #Jatropha curcas #Euphorbiaceae #Cyclic peptides #Protease inhibition activity |
| Tipo |
info:eu-repo/semantics/article |
