Transcriptional and Posttranscriptional Regulations of the HLA-G Gene
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
---|---|
Data(s) |
03/12/2014
03/12/2014
01/01/2014
|
Resumo |
HLA-G has a relevant role in immune response regulation. The overall structure of the HLA-G coding region has been maintained during the evolution process, in which most of its variable sites are synonymous mutations or coincide with introns, preserving major functional HLA-G properties. The HLA-G promoter region is different from the classical class I promoters, mainly because (i) it lacks regulatory responsive elements for IFN-gamma and NF-kappa B, (ii) the proximal promoter region (within 200 bases from the first translated ATG) does not mediate transactivation by the principal HLA class I transactivation mechanisms, and (iii) the presence of identified alternative regulatory elements (heat shock, progesterone and hypoxia-responsive elements) and unidentified responsive elements for IL-10, glucocorticoids, and other transcription factors is evident. At least three variable sites in the 3' untranslated region have been studied that may influence HLA-G expression by modifying mRNA stability or microRNA binding sites, including the 14-base pair insertion/deletion, +3142C/G and +3187A/G polymorphisms. Other polymorphic sites have been described, but there are no functional studies on them. The HLA-G coding region polymorphisms might influence isoform production and at least two null alleles with premature stop codons have been described. We reviewed the structure of the HLA-G promoter region and its implication in transcriptional gene control, the structure of the HLA-G 3' UTR and the major actors of the posttranscriptional gene control, and, finally, the presence of regulatory elements in the coding region. |
Formato |
15 |
Identificador |
http://dx.doi.org/10.1155/2014/734068 Journal Of Immunology Research. New York: Hindawi Publishing Corporation, 15 p., 2014. 1740-2522 http://hdl.handle.net/11449/112291 10.1155/2014/734068 WOS:000333265800001 WOS000333265800001.pdf |
Idioma(s) |
eng |
Publicador |
Hindawi Publishing Corporation |
Relação |
Journal Of Immunology Research |
Direitos |
openAccess |
Tipo |
info:eu-repo/semantics/article |