Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats


Autoria(s): Melo Luvizotto, Renata de Azevedo; Nascimento, Andre F.; Imaizumi, Erika; Pierine, Damiana T.; Conde, Sandro J.; Corrêa, Camila Renata; Yeum, Kyung-Jin; Ferreira, Ana Lúcia dos Anjos
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

03/12/2014

03/12/2014

28/11/2013

Resumo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Processo FAPESP: 10/06100-9

Processo FAPESP: 10/19746-4

Processo FAPESP: 11/19847-8

Processo FAPESP: 11/22786-0

Obesity is characterised by chronic low-grade inflammation, and lycopene has been reported to display anti-inflammatory effects. However, it is not clear whether lycopene supplementation modulates adipokine levels in vivo in obesity. To determine whether lycopene supplementation can regulate adipokine expression in obesity, male Wistar rats were randomly assigned to receive a control diet (C, n 6) or a hyperenergetic diet (DIO, n 12) for 6 weeks. After this period, the DIO animals were randomised into two groups: DIO (n 6) and DIO supplemented with lycopene (DIO + L, n 6). The animals received maize oil (C and DIO) or lycopene (DIO + L, 10 mg/kg body weight (BW) per d) by oral administration for a 6-week period. The animals were then killed by decapitation, and blood samples and epididymal adipose tissue were collected for hormonal determination and gene expression evaluation (IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, leptin and resistin). There was no detectable lycopene in the plasma of the C and DIO groups. However, the mean lycopene plasma concentration was 24 nmol in the DIO + L group. Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations. Also, it significantly reduced the gene expression of MCP-1 in epididymal adipose tissue. Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels. These data suggest that lycopene may be an effective strategy in reducing inflammation in obesity.

Formato

1803-1809

Identificador

http://dx.doi.org/10.1017/S0007114513001256

British Journal Of Nutrition. Cambridge: Cambridge Univ Press, v. 110, n. 10, p. 1803-1809, 2013.

0007-1145

http://hdl.handle.net/11449/112196

10.1017/S0007114513001256

WOS:000326883600007

Idioma(s)

eng

Publicador

Cambridge University Press

Relação

British Journal of Nutrition

Direitos

closedAccess

Palavras-Chave #Lycopene #Obesity #Adipokines
Tipo

info:eu-repo/semantics/article