Increased salivary immunoglobulin A and reduced alpha-amylase activity in whole saliva from spastic cerebral palsy individuals
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
03/12/2014
03/12/2014
01/07/2013
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Resumo |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo FAPESP: 08/00960-6 BACKGROUND: Salivary immunoglobulin A (SIgA) together with innate defenses such as alpha-amylase, provides the 'first line of defense' against pathogens present at mucosal surfaces. This study aimed to evaluate salivary alpha-amylase and immunoglobulin A (IgA) in whole saliva of spastic cerebral palsy (CP) individuals.METHODS: Whole saliva was collected from 22 CP and 24 sibling volunteers with no neurological damage control groups (CG) (aged 7-14 years). The salivary flow rate, total protein and SIgA concentrations, and alpha-amylase activity were determined.RESULTS: The CP group presented higher salivary flow rate (35%) and lower total protein concentration (18%) compared with the CG (P <= 0.05). CPG had higher absolute (68%, mu g SIgA/ml) and relative (55%, mu g SIgA/mg prot and 108%, mu g SIgA/min) concentrations of IgA compared with the CG (P <= 0.05). CPG had lower relative alpha-amylase activity (15% mg malt/mg prot and 33%, mg malt/min) compared with the CG (P <= 0.05).CONCLUSION: This study concluded that CP individuals presented alterations in the profile of salivary proteins involved in the defense system of the oral cavity. |
Formato |
480-485 |
Identificador |
http://dx.doi.org/10.1111/jop.12047 Journal Of Oral Pathology & Medicine. Hoboken: Wiley-blackwell, v. 42, n. 6, p. 480-485, 2013. 0904-2512 http://hdl.handle.net/11449/111741 10.1111/jop.12047 WOS:000321255200008 |
Idioma(s) |
eng |
Publicador |
Wiley-Blackwell |
Relação |
Journal of Oral Pathology & Medicine |
Direitos |
closedAccess |
Palavras-Chave | #salivary immunoglobulin A #alpha-amylase activity #cerebral palsy |
Tipo |
info:eu-repo/semantics/article |