NFAT isoforms regulate muscle fiber type transition without altering can during aerobic training


Autoria(s): Vechetti-Júnior, I. J.; Aguiar, A. F.; De Souza, R. W A; Almeida, F. L A; De Almeida Dias, H. B.; De Aguiar Silva, M. A.; Carani, F. R.; Ferraresso, R. L P; Carvalho, R. F.; Dal-Pai-Silva, M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

03/04/2013

Resumo

The purpose of this study was to determine whether the aerobic training-induced fiber-type transition in different muscles is associated with alterations in NFAT isoforms gene expression. We hypothesized that the aerobic training-induced fiber-type transition would be mediated by NFATc1-c3 isoforms without altering the CaN expression. Male Wistar rats (80 days old) were divided into a trained group (T; n=8) that underwent an 8-wk swimming endurance training program (5 days/week) and a control group (C; n=8). After the experimental period, the animals were sacrificed, and the soleus (SOL) and plantaris (PL) muscles were collected for morphometrical, histochemical and molecular analyses. Aerobic training induced a type I-to-type IIA fiber transition in the SOL muscle and a type IIB-to-type IIA fiber transition in the PL muscle, which were concomitant with a significant (p<0.05) increase in NFATc1-c3 gene expression in both the SOL and PL muscles. In contrast, the expression levels of calcineurin (CaN) and NFATc4 remained unchanged. Therefore, our results showed that fiber type switching induced by aerobic training is mediated by NFATc1-c3 isoforms without altering the CaN expression. © Georg Thieme Verlag KG Stuttgart. New York.

Formato

861-867

Identificador

http://dx.doi.org/10.1055/s-0032-1331758

International Journal of Sports Medicine, v. 34, n. 10, p. 861-867, 2013.

0172-4622

1439-3964

http://hdl.handle.net/11449/75056

10.1055/s-0032-1331758

WOS:000325138900003

2-s2.0-84885020871

Idioma(s)

eng

Relação

International Journal of Sports Medicine

Direitos

closedAccess

Palavras-Chave #calcineurin #endurance training #fiber-type #NFAT isoforms #skeletal muscle
Tipo

info:eu-repo/semantics/article