Synthesis and cytotoxicity of a ruthenium nitrosyl nitric oxide donor with isonicotinic acid and a cell penetrating peptide


Autoria(s): Figueiredo, Leonardo Elias; Cilli, Eduardo Maffud; Molina, Roberto Augusto Silva; Espreafico, Enilza Maria; Tfouni, Elia
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

01/02/2013

Resumo

The syntheses and properties of trans-[Ru(NH3) 4(L)(NO)](BF4)3 (L = isonicotinic acid (inaH) (I) or ina-Tat48-60 (II)) are described. Tat48-60, a cell penetrating peptide fragment of the Tat regulatory protein of the HIV virus, was linked to the ruthenium nitrosyl through inaH. I and II release NO after reduction forming trans-[Ru(NH3)4(L)(H2O)]3 +. The IC50 values against B16-F10 melanoma cells of I and II (21 μmol L- 1 and 23 μmol L- 1, respectively) are close to that of the commercially available cisplatin (33 μmol L- 1) and smaller than similar complexes. The cytotoxicity is assigned to the NO released from I and II. © 2012 Elsevier B.V.

Formato

60-63

Identificador

http://dx.doi.org/10.1016/j.inoche.2012.11.007

Inorganic Chemistry Communications, v. 28, p. 60-63.

1387-7003

http://hdl.handle.net/11449/74469

10.1016/j.inoche.2012.11.007

WOS:000315251700013

2-s2.0-84871380423

Idioma(s)

eng

Relação

Inorganic Chemistry Communications

Direitos

closedAccess

Palavras-Chave #B16-F10 melanoma cells #Cell penetrating peptide #Cytotoxicity #Nitric oxide #Ruthenium #Tat48-60
Tipo

info:eu-repo/semantics/article