Activation of central aα-adrenoceptors mediates salivary gland vasoconstriction


Autoria(s): Moreira, Thiago S.; Takakura, Ana C.; Menani, José Vanderlei; Colombari, Eduardo
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

01/02/2013

Resumo

Objective: Peripheral treatment with the cholinergic agonist pilocarpine increases salivary gland blood flow and induces intense salivation that is reduced by the central injection of moxonidine (aα-adrenoceptors/ imidazoline agonist). In the present study, we investigated the effects of the intracerebroventricular (i.c.v.) injection of pilocarpine alone or combined with moxonidine also injected i.c.v. On submandibular/sublingual gland (SSG) vascular resistance. In addition, the effects of these treatments on arterial pressure, heart rate and on mesenteric and hindlimb vascular resistance were also tested. Design: Male Holtzman rats with stainless steel cannula implanted into lateral ventricle and anaesthetized with urethane + α-chloralose were used. Results: Pilocarpine (500 nmol/1 μl) injected i.c.v. Reduced SSG vascular resistance and increased arterial pressure, heart rate and mesenteric vascular resistance. Contrary to pilocarpine alone, the combination of moxonidine (20 nmol/1 μl) and pilocarpine injected i.c.v. Increased SSG vascular resistance, an effect abolished by the pre-treatment with the α2-adrenoceptor antagonist yohimbine (320 nmol/2 μl). The increase in arterial pressure, heart rate and mesenteric resistance was not modified by the combination of moxonidine and pilocarpine i.c.v. Conclusion: These results suggest that the activation of central α2- adrenoceptors may oppose to the effects of central cholinergic receptor activation in the SSG vascular resistance. © 2012 Elsevier Ltd. All rights reserved.

Formato

167-173

Identificador

http://dx.doi.org/10.1016/j.archoralbio.2012.06.017

Archives of Oral Biology, v. 58, n. 2, p. 167-173, 2013.

0003-9969

http://hdl.handle.net/11449/74463

10.1016/j.archoralbio.2012.06.017

WOS:000314199600007

2-s2.0-84874117366

Idioma(s)

eng

Relação

Archives of Oral Biology

Direitos

closedAccess

Palavras-Chave #α2-Adrenergic receptor #Blood flow and vascular resistance #Moxonidine #Parasympathetic #Pilocarpine #Salivary gland #Rattus
Tipo

info:eu-repo/semantics/article