Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): A systematic review of experimental studies in the elderly


Autoria(s): Coelho, Flávia Gomes de Melo; Gobbi, Sebastião; Andreatto, Carla Andreza Almeida; Corazza, Danilla Icassati; Pedroso, Renata Valle; Santos-Galduróz, Ruth Ferreira
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

01/01/2013

Resumo

The objective of this study was to conduct a systematic review of studies that analyzed the effect of physical exercise on the peripheral levels of BDNF in elderly individuals. Method: We conducted a search in PsycINFO, Biological Abstracts, Pubmed, Web of Science, and Science Direct from 1990 to 2011, using the following keywords: physical exercise , physical activity , physical therapy , training , BDNF , neuroplasticity , neurotrophins , neuroplasticity proteins , aged , older , elderly The articles were considered for inclusion in the review if they were studies with elderly, assessed peripheral (serum and/or plasma) BDNF and evaluated an acute exercise or chronic exercise (training). Results: Five randomized controlled trial and one randomized non-controlled trial studies were analyzed. Five out of six studies reported a significantly higher BDNF response to aerobic acute exercise and to aerobic or strength training program in healthy elderly and elderly with different pathologies. Conclusion: It was not possible to establish a recommendation protocol for the type and intensity of physical exercise required to produce an increase in levels BDNF. However, physical exercise, particularly, moderate-intensity exercises seem to be more effective to promote increase the peripheral levels of BDNF in the elderly. © 2012 Elsevier B.V.

Formato

10-15

Identificador

http://dx.doi.org/10.1016/j.archger.2012.06.003

Archives of Gerontology and Geriatrics, v. 56, n. 1, p. 10-15, 2013.

0167-4943

1872-6976

http://hdl.handle.net/11449/74159

10.1016/j.archger.2012.06.003

WOS:000311343300002

2-s2.0-84869504133

Idioma(s)

eng

Relação

Archives of Gerontology and Geriatrics

Direitos

closedAccess

Palavras-Chave #Aging #BDNF #Biomarkers #Physical activity #Review #brain derived neurotrophic factor #aerobic exercise #clinical effectiveness #exercise intensity #experimental study #geriatric patient #human #physical activity #priority journal #randomized controlled trial (topic) #resistance training #review #systematic review (topic) #Aged #Brain-Derived Neurotrophic Factor #Exercise #Humans
Tipo

info:eu-repo/semantics/article