Xenograft enriched with autologous bone marrow in inlay reconstructions: A tomographic and histomorphometric study in rabbit calvaria


Autoria(s): De Oliveira E Silva, Marcelo; Pelegrine, André Antonio; Alves Pinheiro Da Silva, Alexandre; Manhães Júnior, Luiz Roberto; De Mello E Oliveira, Rafael; Gaiba França, Silvana; Aloise, Antonio Carlos; Ferreira, Lydia Masako
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

19/09/2012

Resumo

Objective. The aim of this study was to evaluate the bone healing after the usage of a scaffold enriched with bone marrow. Study Design. Ten rabbits were divided into 2 groups of 5 animals. Bilateral 12 mm diameter defects were created in the parietal bones. In control group Bio-Oss were inserted in both defects and, in experimental group, Bio-Oss enriched with autologous bone marrow were inserted in both defects. In these two groups, one of the calvarial defects was covered with Bio-Gide. The rabbits were sacrified 8 weeks after surgery and both CT and histomorphometric analysis were done. Results. The CT showed a lower remaining defect area in the experimental group covered with Bio-Gide when compared with control group, with and without Bio-Gide. The histomorphometrics showed no difference between groups regarding the non-vital mineralized tissue area. For vital mineralized tissue area, the experimental group covered with Bio-Gide obtained a higher percentage area when compared with control group, with and without Bio-Gide. For non-mineralized tissue area, the experimental group covered with Bio-Gide obtained a lower percentage area when compared with control group, with and without Bio-Gide. Conclusion. Both autologous bone marrow and membrane can contribute to the enhancement of bone healing. Copyright © 2012 Marcelo de Oliveira e Silva et al.

Identificador

http://dx.doi.org/10.1155/2012/170520

International Journal of Biomaterials.

1687-8787

1687-8795

http://hdl.handle.net/11449/73580

10.1155/2012/170520

2-s2.0-84866250839

2-s2.0-84866250839.pdf

Idioma(s)

eng

Relação

International Journal of Biomaterials

Direitos

openAccess

Tipo

info:eu-repo/semantics/article