SFlt-1 and IP-10 in women with early-onset preeclampsia
| Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
|---|---|
| Data(s) |
27/05/2014
27/05/2014
01/04/2011
|
| Resumo |
Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5 pg/mL in preeclamptic women, as compared with 52.28 pg/mL in the controls (P = 0.0028). The mean serum level of sFlt-1 was 13,636 pg/mL in preeclamptic women, as compared with 2020 pg/mL in the controls (P < 0.0001). PlGF levels were significantly lower in women with preeclampsia. © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. |
| Formato |
129-131 |
| Identificador |
http://dx.doi.org/10.1016/j.preghy.2011.02.002 Pregnancy Hypertension, v. 1, n. 2, p. 129-131, 2011. 2210-7789 http://hdl.handle.net/11449/72349 10.1016/j.preghy.2011.02.002 2-s2.0-79952655899 |
| Idioma(s) |
eng |
| Relação |
Pregnancy Hypertension |
| Direitos |
closedAccess |
| Palavras-Chave | #Angiogenic factors #Inflammation #IP-10 #PlGF #Preeclampsia #sFlt-1 #gamma interferon inducible protein 10 #placental growth factor #vasculotropin receptor 1 #adult #chemoluminescence #clinical article #controlled study #cytometry #female #human #hypothesis #immunoassay #inflammation #pathogenesis #preeclampsia #protein blood level |
| Tipo |
info:eu-repo/semantics/article |
