Expression of p53, Ki-67, and CD31 proteins in endometrial polyps of postmenopausal women treated with tamoxifen.
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/12/2010
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Resumo |
This study was undertaken to investigate the expression of p53, Ki-67, and CD31 proteins in endometrial polyps of postmenopausal women treated with tamoxifen (TAM). Postmenopausal women with endometrial polyps treated with TAM (n = 20), postmenopausal women with endometrial polyps without hormone use (n = 20), postmenopausal women with atrophic endometrium (n = 20), and postmenopausal women with endometrial adenocarcinoma (n = 20) were prospectively investigated. Tissue samples were immunohistochemically evaluated by monoclonal antibodies for p53, Ki-67, and CD31. The data were analyzed using the Student t test, analysis of variance, and χ2 to evaluate significant differences between the groups. The level of significance was set at P < 0.05. There was no difference in the expression of p53 between the groups (P = 0.067). The expression of Ki-67 was higher in the polyp samples from TAM-treated women compared with those from the women using no hormone (P = 0.0047) and those from the women with atrophic endometrium (P = 0.008). Samples from the women with endometrial cancer was associated with higher Ki-67 expression compared with the polyp samples from TAM-treated women (P = 0.004). The expression of CD31 was higher in the polyp samples of TAM-treated women compared with that of the samples from the women with atrophic endometrium (P < 0.001) and similar to the polyp samples from the women using no hormone (P = 0.319) and to the samples from the women with endometrial cancer (P = 0.418). The use of TAM in postmenopausal women might be associated with increased cellular proliferation in endometrial polyps without interfering angiogenesis or inactivation of tumor suppressor proteins. |
Formato |
1525-1530 |
Identificador |
http://www.ncbi.nlm.nih.gov/pubmed/21119367 International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, v. 20, n. 9, p. 1525-1530, 2010. 1525-1438 http://hdl.handle.net/11449/72178 WOS:000284822900014 2-s2.0-79957798119 |
Idioma(s) |
eng |
Relação |
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society |
Direitos |
closedAccess |
Palavras-Chave | #antineoplastic hormone agonists and antagonists #CD31 antigen #Ki 67 antigen #pharmacological biomarker #protein p53 #tamoxifen #tumor marker #tumor protein #adenocarcinoma #aged #drug effect #endometrium #endometrium tumor #evaluation #female #human #metabolism #middle aged #pathology #polyp #postmenopause #prognosis #Adenocarcinoma #Aged #Aged, 80 and over #Antigens, CD31 #Antineoplastic Agents, Hormonal #Biomarkers, Pharmacological #Endometrial Neoplasms #Endometrium #Female #Humans #Ki-67 Antigen #Middle Aged #Neoplasm Proteins #Polyps #Postmenopause #Prognosis #Tamoxifen #Tumor Markers, Biological #Tumor Suppressor Protein p53 |
Tipo |
info:eu-repo/semantics/article |