Vernonia polyanthes as a new source of antiulcer drugs


Autoria(s): Barbastefano, Victor; Cola, Maira; Luiz-Ferreira, Anderson; Farias-Silva, Elisângela; Hiruma-Lima, Clélia A.; Rinaldo, Daniel; Vilegas, Wagner; Souza-Brito, Alba R.M.
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

01/12/2007

Resumo

Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action. © 2007 Elsevier B.V. All rights reserved.

Formato

545-551

Identificador

http://dx.doi.org/10.1016/j.fitote.2007.07.003

Fitoterapia, v. 78, n. 7-8, p. 545-551, 2007.

0367-326X

http://hdl.handle.net/11449/70008

10.1016/j.fitote.2007.07.003

2-s2.0-35448985425

Idioma(s)

eng

Relação

Fitoterapia

Direitos

closedAccess

Palavras-Chave #Action mechanisms #Antiulcerogenic activity #Vernonia polyanthes #alcohol #antiulcer agent #carbenoxolone #cimetidine #lansoprazole #n ethylmaleimide #n(g) nitroarginine methyl ester #nonsteroid antiinflammatory agent #piroxicam #plant extract #unclassified drug #vernonia polyanthes chloroformic extract #Vernonia polyanthes extract #vernonia polyanthes methanolic extract #animal experiment #animal model #drug inhibition #drug mechanism #male #medicinal plant #mouse #nonhuman #priority journal #rat #stomach mucosa lesion #vernonia polyanthes #Animals #Anti-Inflammatory Agents, Non-Steroidal #Anti-Ulcer Agents #Dose-Response Relationship, Drug #Ethanol #Male #Phytotherapy #Plant Components, Aerial #Plant Extracts #Rats #Rats, Wistar #Stomach Ulcer #Vernonia
Tipo

info:eu-repo/semantics/article