In vivo clastogenicity assessment of the Austroplenckia populnea (Celastraceae) leaves extract using micronucleus and chromosome aberration assay


Autoria(s): Pugliesi, Gustavo de Carvalho; De Andrade, Sérgio Faloni; Bastos, Jairo Kenupp; Maistro, Edson Luis
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

01/03/2007

Resumo

The clastogenic effect of the A. populnea leaves extract was tested in vivo on bone marrow cells of Wistar rats by evaluating the induction of chromosome aberrations and micronuclei induction on polychromatic erythrocytes. The extract was administered by gavage at doses of 300, 600 and 900mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment. Under the conditions used, A. populnea leaves extract did not induce decrease in mitotic index and did not induce a statistically significant increase in the mean number of micronucleated polychromatic erythrocytes or chromosome aberrations in the bone marrow cells of Wistar rats. © 2007 The Japan Mendel Society.

Formato

1-6

Identificador

http://dx.doi.org/10.1508/cytologia.72.1

Cytologia, v. 72, n. 1, p. 1-6, 2007.

0011-4545

http://hdl.handle.net/11449/69543

10.1508/cytologia.72.1

2-s2.0-34248643172

2-s2.0-34248643172.pdf

Idioma(s)

eng

Relação

Cytologia

Direitos

openAccess

Palavras-Chave #Austroplenckia populnea #Celastraceae #Chromosome aberrations #Micronucleus test #Animalia #Rattus norvegicus
Tipo

info:eu-repo/semantics/article