Inclusion complex of S(-) bupivacaine and 2-hydroxypropyl- β-cyclodextrin: Study of morphology and cytotoxicity
Contribuinte(s) |
Universidade Estadual Paulista (UNESP) |
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Data(s) |
27/05/2014
27/05/2014
01/12/2006
|
Resumo |
Local anesthetics (LA) belong to a class of pharmacological compounds that attenuate or eliminate pain by binding to the sodium channel of excitable membranes, blocking the influx of sodium ions and the propagation of the nerve impulse. S (-) bupivacaine (S(-) bvc) is a local anesthetic of amino-amide type, widely used in surgery and obstetrics for sustained peripheral and central nerve blockade. This article focuses on the characterization of an inclusion complex of S(-) bvc in 2-hydroxypropyl-β-cyclodextrin (HP-β-CD). Differential scanning calorimetry, scanning electron microscopy and X-Ray diffraction analysis showed structural changes in the complex. In preliminary toxicity studies, the cell viability tests revealed that the inclusion complex decreased the toxic effect (p<0.001) produced by S(-) bvc. These results suggest that the S(-) bvc:HP-β-CD inclusion complex represents a promising agent for the treatment of regional pain. |
Formato |
207-212 |
Identificador |
http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/383 Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 27, n. 3, p. 207-212, 2006. 1808-4532 http://hdl.handle.net/11449/69340 2-s2.0-34948870502 2-s2.0-34948870502.pdf |
Idioma(s) |
eng |
Relação |
Revista de Ciências Farmacêuticas Básica e Aplicada |
Direitos |
openAccess |
Palavras-Chave | #Cyclodextrin #Inclusion complex #S(-) bupivacaine #2 hydroxypropyl beta cyclodextrin #bupivacaine #animal cell #cell structure #cell viability #cytotoxicity #differential scanning calorimetry #mouse #nonhuman #scanning electron microscopy #X ray diffraction |
Tipo |
info:eu-repo/semantics/article |