Cardiopulmonary effects of buprenorphine in horses


Autoria(s): Carregaro, Adriano B.; Teixeira Neto, Francisco José; Beier, Suzane L.; Luna, Stélio Pacca Loureiro
Contribuinte(s)

Universidade Estadual Paulista (UNESP)

Data(s)

27/05/2014

27/05/2014

26/10/2006

Resumo

Objective - To investigate the effects of buprenorphine on cardiopulmonary variables and on abdominal auscultation scores in horses. Animals - 6 healthy adult horses. Procedures - Horses were restrained in stocks and allocated to 2 treatments in a randomized crossover design, with 1-week intervals between each treatment. Saline (0.9% NaCl) solution was administered IV as a control, whereas buprenorphine (10 μg/kg, IV) was administered to the experimental group. Cardiopulmonary data were collected for 120 minutes after buprenorphine or saline solution administration. Abdominal auscultation scores were monitored for 2 and 12 hours after drug administration in the control and experimental groups, respectively. Results - Following control treatment, horses remained calm while restrained in the stocks and no significant changes in cardiopulmonary variables were observed throughout the study. Buprenorphine administration caused excitatory phenomena (restlessness and head shaking). Heart rate, cardiac index, and arterial blood pressure were significantly increased after buprenorphine administration until the end of the observational period (120 minutes). Minimal changes were found in arterial blood gas tensions. Abdominal auscultation scores decreased significantly from baseline for 4 hours after buprenorphine administration. Conclusions and Clinical Relevance - Buprenorphine induced excitement and hemodynamic stimulation with minimal changes in arterial blood gas tensions. These effects may impact the clinical use of buprenorphine in horses. Further studies are indicated to investigate the effects of buprenorphine on gastrointestinal motility and fecal output.

Formato

1675-1680

Identificador

http://dx.doi.org/10.2460/ajvr.67.10.1675

American Journal of Veterinary Research, v. 67, n. 10, p. 1675-1680, 2006.

0002-9645

http://hdl.handle.net/11449/69180

10.2460/ajvr.67.10.1675

2-s2.0-33750211737

Idioma(s)

eng

Relação

American Journal of Veterinary Research

Direitos

closedAccess

Palavras-Chave #buprenorphine #opiate #sodium chloride #arterial pressure #auscultation #blood gas tension #cardiopulmonary function #controlled study #drug effect #excitement #female #heart index #heart rate #hemodynamics #horse #male #monitoring #nonhuman #randomization #restlessness #scoring system #Analgesics, Opioid #Animals #Blood Pressure #Buprenorphine #Carbon Dioxide #Cardiac Output #Cross-Over Studies #Female #Heart Rate #Horses #Male #Oxygen #Random Allocation #Animalia #Equidae
Tipo

info:eu-repo/semantics/article